SAB1309036

Anti-phospho-rat TSC1(S1141) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Hamartin, Tuberous sclerosis 1 protein homolog, Tsc1
• UNSPSC Code: 12352203

Properties

• biological source: (Rat)
• conjugate: unconjugated
• antibody form: purified antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: liquid
• mol wt: 129022Da
• species reactivity: rat
• technique(s): dot blot: 1:500
• isotype: IgG
• NCBI accession no.: NP_068626.1
• storage temp.: -10 to -25°C
• target post-translational modification: phosphorylation (pSer1141)
• Gene Information: rat ... Tsc1(60445)

Description

General description

In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).

Specificity

This rat TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1141 of rat TSC1.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable