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Key Documents

SAB1304574

Sigma-Aldrich

ANTI-TET2 (N-TERM) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

KIAA1546, Probable methylcytosine dioxygenase TET2, TET2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

223811 Da

species reactivity

human

technique(s)

western blot: 1:1000

NCBI accession no.

NP_001120680.1
NP_060098.3

UniProt accession no.

Q6N021

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TET2(54790)

General description

Tet methyl cytosine dioxygenase 2 (TET2), a TET oncogene family member 2/ten-eleven translocation 2, is a tumour suppressor gene which encodes a DNA demethylase enzyme. In human chromosome, the gene TET2 is localized on 4q24.

Biochem/physiol Actions

Tet methyl cytosine dioxygenase 2 (TET2) catalyses the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. TET2 is essential for normal myelopoiesis, epigenetic programming, embryonic stem cell maintenance and early development. Mutations in TET2 leads to myelodysplastic syndromes (MDS), myeloproliferative disorder, myeloproliferative neoplasms (MPN). Mutations also causes different leukaemia like chronic myelomonocytic leukaemia (CMML), acute myeloid leukaemias (AML), secondary AML (sAML) and myeloid malignancies. TET2 regulates mast cell differentiation and proliferation and cytokine production.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
SA111206AX
SA100617AL

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Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
Ko M, et al.
Nature, 468(7325), 839-839 (2010)
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
Figueroa ME, et al.
Cancer Cell, 18(6), 553-567 (2010)
Mutation in TET2 in myeloid cancers
Delhommeau F, et al.
The New England Journal of Medicine, 360(22), 2289-2301 (2009)
TET2 regulates mast cell differentiation and proliferation through catalytic and non-catalytic activities
Montagner S, et al.
Cell Reports, 15(7), 1566-1579 (2016)
The role of TET2 in hematologic neoplasms
Holmfeldt L and Mullighan CG
Cancer Cell, 20(1), 1-2 (2011)

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