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P4124

Sigma-Aldrich

Anti-PM/Scl-100 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Autoantigen PM/Scl 2, Anti-EXOSC10, Anti-Exsosome Component 10, Anti-P100, Anti-PMSCL Autoantigen, 100-KD, Anti-PMSCL2, Anti-Polymyositis-scleroderma Overlap Syndrome Associated Autoantigen, Anti-Polymyositis/scleroderma Autoantigen 2, Anti-Polymyositis/scleroderma Autoantigen, 100 kDa

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5 MG
SGD 164.00

SGD 164.00

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5 MG
SGD 164.00

About This Item

MDL number:
MFCD08705502
UNSPSC Code:
12352203
NACRES:
NA.41

SGD 164.00

Please contact Customer Service for Availability
Request a Bulk Order

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~100 kDa

species reactivity

human, rat, mouse

concentration

~1.0 mg/mL

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This Item
R5250R5000R5125
Ribonuclease A from bovine pancreas 4×cryst., ~70 U/mg (acc. to Kunitz)

83834

Ribonuclease A from bovine pancreas

Ribonuclease A from bovine pancreas Type X-A, ≥90% (SDS-PAGE), ≥70 Kunitz units/mg protein

R5250

Ribonuclease A from bovine pancreas

Ribonuclease A from bovine pancreas Type II-A, ≥60% (SDS-PAGE), >= 60 Kunitz units/mg protein

R5000

Ribonuclease A from bovine pancreas

Ribonuclease A from bovine pancreas Type III-A, ≥85% RNase A basis (SDS-PAGE), 85-140 Kunitz units/mg protein

R5125

Ribonuclease A from bovine pancreas

form

powder

form

buffered aqueous solution

form

solid

form

lyophilized powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

shipped in

wet ice

shipped in

-

shipped in

-

shipped in

-

mol wt

~13,700, Mr ~13700

mol wt

~13,700

mol wt

~13,700

mol wt

~13,700

impurities

proteases, none detected

impurities

-

impurities

salt, essentially free

impurities

salt, essentially free

General description

PM/SCL-100 (human exosome) is also known as RRP6, EXOSC10 (exosome component 10). It is a heterogeneous autoantibody that is located on human chromosome 1p36. In mouse, EXOSC10 is located on XY body.

Immunogen

synthetic peptide corresponding to amino acid residues 231-245 of human PM/Scl-100 with an N-terminal added cysteine, conjugated to KLH. The corresponding sequence is identical in both rat and mouse PM/Scl-100.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Western Blotting (1 paper)

Biochem/physiol Actions

PM/SCL-100 (human exosome) participates in ribosome biogenesis, snoRNA (small nucleolar RNAs)processing, surveillance and degradation of nonfunctional transcripts. It is essential for the production of 40S subunit and to maintain global translation. EXOSC10 participates in mitotic cell division. In mouse, Exosc10 is required for spermatogonial proliferation and early embryogenesis.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    114M4814V
    048M4809V
    21180127
    014M4775
    082M4848

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    Find documentation for the products that you have recently purchased in the Document Library.

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    Differential expression between human dermal papilla cells from balding and non-balding scalps reveals new candidate genes for androgenetic alopecia.
    Chew EG, et al.
    The Journal of Investigative Dermatology, 136(8), 1559-1567 (2016)
    Novel aspects of autoantibodies to the PM/Scl complex: clinical, genetic and diagnostic insights.
    Mahler M and Raijmakers R
    Autoimmunity Reviews, 6(7), 432-437 (2007)
    EXOSC10/Rrp6 is post-translationally regulated in male germ cells and controls the onset of spermatogenesis.
    Jamin SP, et al.
    Scientific Reports, 7(1), 15065-15065 (2017)
    Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis.
    Knight JR et al
    RNA, 22(4), 623-635 (2016)
    Tatyana Kent et al.
    RNA (New York, N.Y.), 15(1), 14-20 (2008-11-26)
    The 5' external transcribed spacer (5'ETS) is critical for 18S rRNA formation and is the longest noncoding region in a ribosomal RNA transcript. Here we show that processing in mouse 5'ETS involves two cleavage events. Processing at site A' corresponds
    View All Related Papers

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