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Sigma-Aldrich

MISSION® LightSwitch Luciferase Assay Reagent™

Fully optimized reporter system

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About This Item

UNSPSC Code:
41106609
NACRES:
NA.84

Quality Level

200

product line

MISSION®

storage temp.

−20°C

General description

The MISSION LightSwitch Luciferase Assay Reagent enables one-step reagent addition to measure luciferase reporter signal. The MISSION LightSwitch Luciferase Assay Reagent and the MISSION 3′UTR Lenti GoClone report constructs are a fully optimized reporter system that includes an improved reporter gene (RenSP), an optimized assay reagent, and a genome-wide collection of 3′UTR Lenti GoClone reporter constructs. The MISSION 3′UTR Lenti GoClone reporter constructs have been optimized for use with the MISSION LightSwitch Assay Reagent.

Application

MISSION® LightSwitch™ Luciferase Assay Reagent has been used to measure actin promoter activity.

Legal Information

LightSwitch is a trademark of Active Motif
MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany
SwitchGear Genomics is a trademark of SwitchGear Genomics

Kit Components Also Available Separately

Product No.
Description
SDS
  • MISSION® LightSwitch Assay Reagent™ Substrate
  • MISSION® LightSwitch Assay Reagent™ Buffer
  • MISSION® LightSwitch Assay Reagent™ Solvent

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Storage Class

3 - Flammable liquids

flash_point_f

51.8 °F

flash_point_c

11 °C

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The PLA2R1-JAK2 pathway upregulates ERRa and its mitochondrial program to exert tumor-suppressive action.
Griveau A
Oncogene, 35(38), 5033-5042 (2016)
Nathan D Trinklein et al.
Genome research, 14(1), 62-66 (2004-01-07)
The alignment of full-length human cDNA sequences to the finished sequence of the human genome provides a unique opportunity to study the distribution of genes throughout the genome. By analyzing the distances between 23,752 genes, we identified a class of
Nathan D Trinklein et al.
Genome research, 13(2), 308-312 (2003-02-05)
Genomic and full-length cDNA sequences provide opportunities for understanding human gene structure and transcriptional regulatory elements. The simplest regulatory elements to identify are promoters, as their positions are dictated by the location of transcription start sites. We aligned full-length cDNA
An NTD-associated polymorphism in the 3' UTR of MTHFD1L can affect disease risk by altering miRNA binding.
Minguzzi S
Human Mutation, 35(1), 96-104 (2014)
Federico Innocenti et al.
PLoS genetics, 7(5), e1002078-e1002078 (2011-06-04)
The discovery of expression quantitative trait loci ("eQTLs") can help to unravel genetic contributions to complex traits. We identified genetic determinants of human liver gene expression variation using two independent collections of primary tissue profiled with Agilent (n = 206) and Illumina
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Articles

Lenti GoClone

Validate miRNA targets and study post-transcriptional gene regulation with lentiviral 3'UTR reporters.

Genome-wide Collection of Lenti 3’UTR Reporters for Functional Validation of microRNA Targets

Sigma-Aldrich presents an article about microRNAs (miRNAs), which are a class of naturally occurring small non-coding RNA molecules that regulate a variety of developmental and physiological processes.

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