L9668

Lidoflazine

≥98% (HPLC), powder

• Synonym(s): 4-[4,4-Bis(4-fluorophenyl)butyl]-N-(2,6-dimethylphenyl)-1-piperazineacetamide
• Empirical Formula (Hill Notation): C₃₀H₃₅F₂N₃O
• CAS Number: 3416-26-0
• Molecular Weight: 491.62
• EC Number: 222-312-8
• MDL number: MFCD00057353
• UNSPSC Code: 12352200
• PubChem Substance ID: 329817673
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white
• solubility: DMSO: ≥10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cc1cccc(C)c1NC(=O)CN2CCN(CCCC(c3ccc(F)cc3)c4ccc(F)cc4)CC2
• InChI: 1S/C30H35F2N3O/c1-22-5-3-6-23(2)30(22)33-29(36)21-35-19-17-34(18-20-35)16-4-7-28(24-8-12-26(31)13-9-24)25-10-14-27(32)15-11-25/h3,5-6,8-15,28H,4,7,16-21H2,1-2H3,(H,33,36)
• InChI key: ZBIAKUMOEKILTF-UHFFFAOYSA-N

Description

Biochem/physiol Actions

HERG calcium channel blocker

Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia. It prolongs QT interval by blocking HERG channel. IC₅₀ < 0.1 μM

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves