K4264

KR-62436 hydrate

≥95%, powder

• Synonym(s): 6-{2-[(5-Cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile dihydrochloride hydrate
• Empirical Formula (Hill Notation): C₁₄H₁₅N₇O·2HCl · xH₂O
• CAS Number: 761414-79-3
• Molecular Weight: 370.24 (anhydrous basis)
• MDL number: MFCD17215675
• UNSPSC Code: 51111800
• PubChem Substance ID: 24724521
• NACRES: NA.77

Properties

• assay: ≥95%
• form: powder
• color: white to beige
• solubility: H₂O: 5 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O.Cl.Cl.O=C(CNCCNc1ccc(cn1)C#N)N2N=CCC2C#N
• InChI: 1S/C14H15N7O.2ClH.H2O/c15-7-11-1-2-13(19-9-11)18-6-5-17-10-14(22)21-12(8-16)3-4-20-21;;;/h1-2,4,9,12,17H,3,5-6,10H2,(H,18,19);2*1H;1H2
• InChI key: FQZOFSJMRKZMSV-UHFFFAOYSA-N

Description

Biochem/physiol Actions

KR-62436 is a competitive inhibitor of dipeptidyl peptidase-IV (DPP-IV). DPP-IV is a serine protease which inactivates glucagon-like peptide (GLP-1); IC₅₀ 0.1-0.8 μM; GLP-1 is a potent stimulus for insulin secretion and inducer of satiety after food intake, but it has a very short action (1 min) because it is rapidly degraded by DPP-IV; blocking DPP-IV increases GLP-1 action and increases plasma insulin levels; DPP-IV inhibitors and KR-62436 have clinical potential as anti-diabetic agents

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves