K1140

Kifunensine

solid,film or powder, ≥98%

• Synonym(s): FR 900494, Hexahydro-6R,7S,8aS-trihydroxy-5R-(hydroxymethyl)-imidazo[1,2-a] pyridine-2,3-dione
• Empirical Formula (Hill Notation): C₈H₁₂N₂O₆
• CAS Number: 109944-15-2
• Molecular Weight: 232.19
• UNSPSC Code: 12352204
• NACRES: NA.77

Properties

• Product Name: Kifunensine, mannosidase inhibitor
• biological source: synthetic (organic)
• Quality Level: 100
• assay: ≥98%
• form: film or powder; solid
• solubility: water, double-distilled: 50 mM
• storage temp.: −20°C
• SMILES string: N21[C@H](NC(=O)C2=O)[C@H]([C@H]([C@@H]([C@H]1CO)O)O)O
• InChI: 1S/C8H12N2O6/c11-1-2-3(12)4(13)5(14)6-9-7(15)8(16)10(2)6/h2-6,11-14H,1H2,(H,9,15)/t2-,3-,4+,5+,6+/m1/s1
• InChI key: OIURYJWYVIAOCW-PQMKYFCFSA-N
• Gene Information: human ... MAN1A1(4121) , MAN1A2(10905) , MAN1B1(11253) , MAN1C1(57134) ; mouse ... MAN1A1(17155) , MAN1A2(17156) , MAN1B1(227619) , MAN1C1(230815) ; rat ... MAN1A1(294410) , MAN1A2(295319) , MAN1B1(499751) , MAN1C1(362625)

Description

General description

Kifunensine is an alkaloid compound, isolated from the actinomycete Kitasporia kifunensis.

Application

Kifunensine has been used as an inhibitor of mannosidase I in Jurkat T-cells, human embryonic kidney (HEK293T/17) cells and in mouse embryonic fibroblast cells.

Biochem/physiol Actions

Kifunensine is a selective inhibitor of class I glycoprotein-processing α-mannosidases.

Kifunensine suppresses endoplasmic reticulum-associated degradation (ERAD) via the inhibition of endoplasmic reticulum-associated mannosidase activity. It is also a glycosidase inhibitor for Class I CAZy glycosylhydrolase family 47.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)