HPA039325
Anti-SDPR antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Synonym(s):
Anti-Cavin-2, Anti-Ps-p68, Anti-Sdr, Anti-Serum deprivation response
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About This Item
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
enhanced validation
orthogonal RNAseq
Learn more about Antibody Enhanced Validation
technique(s)
immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:2500-1:5000
General description
Serum deprivation protein response (SDPR) gene is mapped to human chromosome 2q32-q33. The gene codes for phosphatidylserine-binding protein, PS-p68.
Immunogen
serum deprivation response recombinant protein epitope signature tag (PrEST)
Application
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-SDPR antibody produced in rabbit has been used in the immunohistochemical and western blot analysis.
Biochem/physiol Actions
Serum deprivation protein response (SDPR) might be involved in platelet aggregation/secretion by facilitating the migration of platelet protein kinase C substrate, pleckstrin, to the plasma membrane in conjunction with phosphoinositides that bind to the C-terminal pleckstrin homology (PH) domain. SDPR assists binding of polymerase I and transcript release factor (PTRF) to caveolar membranes and plays a vital role in formation of caveolar invaginations. Thus, knock down or mutation of SDPR causes loss of caveolae and elevated expression of the protein leads to caveolae deformation and membrane tubulation. SDPR functions as a tumor suppressor in breast cancer.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Linkage
Corresponding Antigen APREST72701
Physical form
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Find documentation for the products that you have recently purchased in the Document Library.
The platelet protein kinase C substrate pleckstrin binds directly to SDPR protein.
Baig A
Platelets, 20, 446-457 (2009)
The human serum deprivation response gene (SDPR) maps to 2q32-q33 and codes for a phosphatidylserine-binding protein.
Gustincich S
Genomics, 57, 120-129 (1999)
Increases in endothelial caveolin-1 and cavins correlate with cirrhosis progression.
Yokomori H
Micron (Oxford, England : 1993), 76, 52-61 (2015)
SDPR induces membrane curvature and functions in the formation of caveolae.
Hansen CG
Nature Cell Biology, 11, 807-814 (2009)
SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis.
Ozturk S
Proceedings of the National Academy of Sciences of the USA, 113, 638-643 (2016)
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