F1429
Anti-Fe65 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
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About This Item
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 97 kDa
species reactivity
mouse
technique(s)
western blot: suitable using mouse brain lysate
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
mouse ... Apbb1(11785)
Specificity
The antibody does not detect endogenous levels of Fe65.
Immunogen
synthetic peptide corresponding to amino acid residues 352-369 from mouse Fe65.
Application
Anti-Fe65 antibody produced in rabbit is suitable for western blotting using mouse brain lysate.
Biochem/physiol Actions
Amyloid β A4 precursor protein-binding family B member 1 is a protein encoded by the APBB1 gene in humans and is mapped on human metaphase chromosomes to band 11p15. Fe65 is a neuronal adaptor protein that is involved in brain development, Alzheimer disease amyloid precursor protein (APP) signaling and proteolytic processing of APP. It participates in various processes by recruiting various interacting partners to form functional complexes and acts as a novel regulator of neurite outgrowth. Fe65 significantly alters actin dynamics and mitochondrial function in neuronal cells.
Physical form
Solution in phosphate buffered saline containing 1.0 mg/mL bovine serum albumin and 0.05% sodium azide.
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Storage Class
10 - Combustible liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Hei Nga Maggie Cheung et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(1), 337-349 (2013-09-24)
FE65 is an adaptor protein that binds to the amyloid precursor protein (APP). As such, FE65 has been implicated in the pathogenesis of Alzheimer's disease. In addition, evidence suggests that FE65 is involved in brain development. It is generally believed
Claus U Pietrzik et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(17), 4259-4265 (2004-04-30)
Increasing evidence has implicated the low density lipoprotein receptor-related protein (LRP) and the adaptor protein FE65 in Alzheimer's disease pathogenesis. We have shown previously that LRP mediates beta-amyloid precursor protein (APP) processing and affects amyloid beta-protein and APP secretion and
Shasta L Sabo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(13), 5407-5415 (2003-07-05)
Although the Alzheimer amyloid protein precursor (APP) has been studied intensely for more than a decade, its function in neurons is unresolved. Much less is known about its binding partner FE65. We have shown recently that APP and FE65 synergistically
S L Bressler et al.
Human molecular genetics, 5(10), 1589-1598 (1996-10-01)
Using the yeast two hybrid system, a mouse embryo cDNA library was screened for proteins that interact with the C-terminus of the human beta-amyloid precursor protein (beta PP). A fusion protein was identified that interacts specifically with the cytoplasmic domain
Jens Radzimanowski et al.
The Journal of biological chemistry, 283(34), 23113-23120 (2008-06-14)
The neuronal adaptor protein Fe65 is involved in brain development, Alzheimer disease amyloid precursor protein (APP) signaling, and proteolytic processing of APP. It contains three protein-protein interaction domains, one WW domain, and a unique tandem array of phosphotyrosine-binding (PTB) domains.
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