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Key Documents

AV38701

Sigma-Aldrich

Anti-MEOX2 (AB3) antibody produced in rabbit

IgG fraction of antiserum

Synonym(s):

Anti-Mesenchyme homeobox 2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

33 kDa

species reactivity

rabbit, guinea pig, bovine, horse, human, dog

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_005915

UniProt accession no.

P50222

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... MEOX2(4223)

Immunogen

Synthetic peptide directed towards the C terminal region of human MEOX2

Biochem/physiol Actions

MEOX2 is a transcription regulator that is essential for limb myogenesis in vertebrates. It regulates the activity of NF-κB and inhibits the activation of vascular endothelial cells in response to hypoxia and proangiogenic factors. MEOX1 and 2 regulate the activity cyclin dependent kinase inhibitors p21(CIP1/WAF1) and p16(INK4a) and induce cell cycle arrest in endothelial cells.

Sequence

Synthetic peptide located within the following region: REKELVNVKKGTLLPSELSGIGAATLQQTGDSIANEDSHDSDHSSEHAHL

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
QC8360

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Yun Chen et al.
Cardiovascular research, 87(4), 723-731 (2010-04-28)
Tumours secrete proangiogenic factors to induce the ingrowth of blood vessels, the end targets of which are vascular endothelial cells (ECs). The MEOX2 homeoprotein inhibits nuclear factor-kappaB (NF-kappaB) signalling and EC activation in response to serum and proangiogenic factors. We
Josette M Douville et al.
PloS one, 6(12), e29099-e29099 (2011-12-30)
Senescence, the state of permanent cell cycle arrest, has been associated with endothelial cell dysfunction and atherosclerosis. The cyclin dependent kinase inhibitors p21(CIP1/WAF1) and p16(INK4a) govern the G(1)/S cell cycle checkpoint and are essential for determining whether a cell enters
Susan Reijntjes et al.
The International journal of developmental biology, 51(8), 753-759 (2007-10-17)
We have examined the expression pattern of the avian Meox1 homeobox gene during early development and up to late limb bud stages. Its expression pattern indicates that it is involved in somite specification and differentiation. The domains of expression are

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