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Supelco

Daidzein

analytical standard

Synonym(s):

4′,7-Dihydroxy­iso­flavone, 7-Hydroxy-3-(4-hydroxy­phenyl)-4H-1-benzo­pyran-4-one, 7-Hydroxy-3-(4-hydroxy­phenyl)­chromone, Isoaurostatin

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About This Item

Empirical Formula (Hill Notation):
C15H10O4
CAS Number:
486-66-8
Molecular Weight:
254.24
Beilstein/REAXYS Number:
231523
EC Number:
207-635-4
MDL number:
MFCD00016954
UNSPSC Code:
85151701
PubChem Substance ID:
329751271
NACRES:
NA.24
Pricing and availability is not currently available.

grade

analytical standard

Quality Level

100

assay

≥97.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

storage temp.

2-8°C

SMILES string

Oc1ccc(cc1)C2=COc3cc(O)ccc3C2=O

InChI

1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H

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Show Differences

1 of 4

This Item
1478403O1385A114
Olopatadine hydrochloride ≥98% (HPLC)

O0391

Olopatadine hydrochloride

Olopatadine hydrochloride United States Pharmacopeia (USP) Reference Standard

1478403

Olopatadine hydrochloride

Ozagrel hydrochloride hydrate ≥98% (HPLC), solid

O1385

Ozagrel hydrochloride hydrate

(+)-N-Allylnormetazocine hydrochloride ≥98% (HPLC)

A114

(+)-N-Allylnormetazocine hydrochloride

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

-

storage temp.

room temp

storage temp.

room temp

solubility

H2O: ≥20 mg/mL

solubility

-

solubility

H2O: soluble

solubility

H2O: >10 mg/mL

Gene Information

human ... HRH1(3269)

Gene Information

human ... HRH1(3269)

Gene Information

-

Gene Information

human ... OPRS1(10280)

General description

Daidzein is an endocrine-active estrogenic isoflavone. This phytoestrogen is capable to bind to estrogen to exert estrogenic effects in vivo. It can naturally be found in soybean seed and flour.[1]

Application

Daidzein was used as standard in determination of daidzein and genistein, in soybean food using in-tube solid-phase microextraction coupled to high-performance liquid chromatography (in-tube SPME–HPLC).[2] It was also used as reference standard in determination of isoflavones in red clover using high-performance liquid chromatography–UV–electrospray ionization-mass spectrometric detector (HPLC–UV–ESI-MSD).[3]
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Soy isoflavone daidzein protects against oxidative damage in liver cells induced by 7,12-dimethylbenz[a]anthracene (DMBA). Catalase and superoxide dismutase activity, down-regulated by DMBA, was restored by daidzein.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    WXBD5206V
    WXBD1344V
    WXBC8222V
    WXBC6768V
    WXBC5866V

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    Sigma-Aldrich

    G2785

    Glycitein

    Daidzein Inactive analog of Genistein.

    Sigma-Aldrich

    251600

    Daidzein

    Glycitin phyproof® Reference Substance

    PHL89693

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    Supelco

    94334

    Formononetin

    Genistein synthetic, ≥98% (HPLC), powder

    Sigma-Aldrich

    G6649

    Genistein

    Developmental effects of dietary phytoestrogens in Sprague-Dawley rats and interactions of genistein and daidzein with rat estrogen receptors alpha and beta in vitro.
    Casanova, Mercedes, et al.
    Toxicological Sciences, 51.2, 236-244 (1999)
    Determination of isoflavones in red clover and related species by high-performance liquid chromatography combined with ultraviolet and mass spectrometric detection.
    Wu Q, Wang M, Simon JE.
    Journal of Chromatography A, 1016(2), 195-209 (2003)
    Determination of daidzein and genistein in soybean foods by automated on-line in-tube solid-phase microextraction coupled to high-performance liquid chromatography.
    Mitani K, Narimatsu S, Kataoka H.
    Journal of Chromatography A, 986(2), 169-177 (2003)
    Katherine A Jackman et al.
    Current medicinal chemistry, 14(26), 2824-2830 (2007-11-30)
    Isoflavones are an important class of phytoestrogens that are found at extrememly high levels in soy. Up until recently, daidzein and genistein were considered to be the most important and hence most studied isoflavones, however more recently attention has shifted
    Ivonne M C M Rietjens et al.
    Molecular nutrition & food research, 57(1), 100-113 (2012-11-24)
    Isoflavones are phytoestrogens that have been linked to both beneficial as well as adverse effects in relation to cell proliferation and cancer risks. The present article presents an overview of these seemingly contradicting health effects and of mechanisms that could
    View All Related Papers

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