ABN347

Anti-LGI4 Antibody

from rabbit, purified by affinity chromatography

• Synonym(s): Leucine-rich repeat LGI family member 4, LGI1-like protein 3, Leucine-rich glioma-inactivated protein 4, LGI4
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• purified by: affinity chromatography
• species reactivity: human
• technique(s): western blot: suitable
• UniProt accession no.: Q8N135
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... LGI4(163175)

Description

General description

The leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs). Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI4 have not been found to be associated with autodominant lateral temporal epilepsy (ADTLE). However, the LGI4 gene is located in a region linked to benign familial infantile convulsions and a GC-to-AT polymorphism in LGI4 was correlated with childhood absence epilepsy. Other studies showed that decreasing LGI4 expression in cultured cells inhibits myelination, indicating that LGI4 may play a role in neural development.

Specificity

Two isoforms of LGI4 are known to exist; this LGI4 antibody will recognize only the larger form. This LGI4 antibody is predicted to be specific to LGI4 and not recognize other LGI proteins.

Immunogen

KLH-conjugated linear peptide corresponding to human LGI4.

Application

Detect the LGI4 protein using this Anti-LGI4 validated for use in WB.

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

Quality

Evaluated by Western Blot in human brain tissue lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected LGI4 in 15 µg of human brain tissue lysate.

Target description

~59 kDa observed

Physical form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS and 0.02% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Human brain tissue lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1