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Key Documents

AB6031

Sigma-Aldrich

Anti-Integrin alpha-11 Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

Integrin alpha-11

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

species reactivity (predicted by homology)

mouse (based on 100% sequence homology), rat (based on 100% sequence homology)

technique(s)

western blot: suitable

NCBI accession no.

NP_001004439

General description

Integrin alpha-11 (ITGA11) belongs to a family of cell adhesion molecules, which consist of noncovalent associated alpha-beta heterodimers, and is shown to be overexpressed in the stroma of human non-small-cell lung carcinomas (hNSCLCs). Upon dimerization, this protein is thought to enhance tumorgenicity of hNSCLCs by interacting with matrix collagen and stromal fibroblasts. Progesterone is shown to increase the expression of ITGA11 through mid-gestation and decrease thereafter in Sprague-Dawley rats. It is further indicated that MAPK signaling is associated with the regulation of these integrins.

Immunogen

Linear peptide corresponding to human Integrin alpha-11.

Application

Anti-Integrin alpha-11 Antibody is an antibody against Integrin alpha-11 for use in WB.
Research Category
Cell Structure
Research Sub Category
Integrins

Quality

Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected Integrin alpha-11 in 10 µg of non-boiled & non-B-ME HeLa cell lysate.

Target description

~135 kDa observed.
The high molecular weight band seen in a HeLa (non boiled) cell lysate is the integrin complex. The band at ~75-80 kDa is thought to be a denatured form of integrin.

Physical form

Affinity purified
Purified rabbit polyclonal containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Non-boiled & non-B-ME HeLa cell lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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