M2876

(±)-α-Methoxyphenylacetic acid

crystalline

• Synonym(s): O-Methyl-DL-mandelic acid, MOPA
• Linear Formula: C₆H₅CH(OCH₃)COOH
• CAS Number: 7021-09-2
• Molecular Weight: 166.17
• Beilstein/REAXYS Number: 2209197
• EC Number: 230-300-9
• MDL number: MFCD00064217
• UNSPSC Code: 12352100
• PubChem Substance ID: 57654368
• NACRES: NA.22

Properties

• assay: ≥99.0%
• Quality Level: 200
• form: crystalline
• bp: 165 °C ((lit.)); 165 °C/18 mmHg (lit.)
• mp: 69-71 °C (lit.); 69-71 °C
• SMILES string: COC(C(O)=O)c1ccccc1
• InChI: [1S/C9H10O3/c1-12-8(9(10)11)7-5-3-2-4-6-7/h2-6,8H,1H3,(H,10,11)]; 1S/C9H10O3/c1-12-8(9(10)11)7-5-3-2-4-6-7/h2-6,8H,1H3,(H,10,11)
• InChI key: [DIWVBIXQCNRCFE-UHFFFAOYSA-N]; DIWVBIXQCNRCFE-UHFFFAOYSA-N

Description

General description

(±)-α-Methoxyphenylacetic acid, also known as MOPA is commonly used as a resolving agent and building block in various organic synthesis.

Application

(±)-α-Methoxyphenylacetic acid can be used as a reactant to synthesize:      

• N

• -(Cyclohexylmethyl)-2-methoxy-2-phenylethylamine by reacting with cyclohexylmethylamine in the presence of EDCI/HOBt/Et₃N.      
• 4-(methoxyphenylmethyl)-2-methylpyridine by reacting with 2-methyl-4-pyridinecarbonitrile via decarboxylative arylation reaction in the presence of a photocatalyst.

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H318
• pcodes: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves