924520

4-Methoxybenzyl chloride

• Synonym(s): 4-(Chloromethyl)anisole
• Linear Formula: CH₃OC₆H₄CH₂Cl
• CAS Number: 824-94-2
• Molecular Weight: 156.61
• Beilstein/REAXYS Number: 606667
• MDL number: MFCD00000915
• UNSPSC Code: 41116105
• NACRES: NA.22

Properties

• form: liquid
• Quality Level: 100
• refractive index: n20/D 1.548 (lit.)
• bp: 117-118 °C/14 mmHg (lit.)
• mp: −1 °C (lit.)
• density: 1.155 g/mL at 25 °C (lit.)
• functional group: chloro
• storage temp.: 2-8°C
• SMILES string: COc1ccc(CCl)cc1
• InChI: 1S/C8H9ClO/c1-10-8-4-2-7(6-9)3-5-8/h2-5H,6H2,1H3
• InChI key: MOHYOXXOKFQHDC-UHFFFAOYSA-N

Description

Application

4-Methoxybenzyl chloride can be used as a reactant:

• To synthesize 4-methoxybenzyl esters by reacting with cyclic anhydrides.
• In the mono-alkylation of trans-1,2-diaminocyclohexane.

It can also be used as a:

• Protecting group for amino acids during peptide synthesis using triethylamine as a base.
• Co-catalyst in the intramolecular carboamination of aminodienes to N-heterocyclesvia benzyl-group transfer.

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H314
• pcodes: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1B
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk_germany: WGK 3
• flash_point_f: 228.2 °F - closed cup
• flash_point_c: 109 °C - closed cup