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913235

Sigma-Aldrich

Acetylated branched polyethylenimine solution

20% acetylation, suitable for biomedical research

Synonym(s):

Acetylated PEI, Acetylated-PEI25K, Capped PEI

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About This Item

Linear Formula:
(C29H63N11O3)mC3H8N2O
UNSPSC Code:
12162002
NACRES:
NA.23

Product Name

Acetylated branched polyethylenimine solution 20% solution, 20% acetylation, suitable for biomedical research

Quality Level

100

form

liquid

concentration

20 wt. % in water

color

pale yellow to yellow

storage temp.

2-8°C

Related Categories

Application

High molecular weight branched PEI is commonly used in gene delivery due to its high transfection efficiency in a broad range of cells. Branched PEI has been used to successfully deliver genetic material both in vitro and in vivo. N-Acetylation of PEI could lower its toxicity. At low degree of substitution (below 25%) resulted in moderate improvement of transfection activity.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

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M Laird Forrest et al.
Pharmaceutical research, 21(2), 365-371 (2004-03-23)
Polyethylenimine (PEI) is a highly effective gene delivery vector, but because it is an off-the shelf material, its properties may not be optimal. To investigate the effects of the protonation properties of the polymer, we generated PEI derivatives by acetylating
Nathan P Gabrielson et al.
Biomacromolecules, 7(8), 2427-2435 (2006-08-15)
We previously reported that gene delivery efficiency of 25-kDa, branched polyethylenimine (PEI) increased upon acetylation of up to 43% of the primary amines with acetic anhydride. In the present work, we investigated the effects of further increasing the degree of
Arkadi Zintchenko et al.
Bioconjugate chemistry, 19(7), 1448-1455 (2008-06-17)
Polymer carriers like PEI which proved their efficiency in DNA delivery were found to be far less effective for the applications with siRNA. In the current study, we generated a number of nontoxic derivates of branched PEI through modification of

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Recent Progress on Nonviral Delivery Carriers for CRISPR/Cas9 Systems

The CRISPR/Cas9 system has recently emerged as a highly specific, efficient, and versatile gene editing technology that can be utilized to build disease models and correct diseased genes. Safe and effective delivery vectors for the CRISPR/Cas9 system are in critical need to enable clinical development and future applications of CRISPR/Cas9 systems. Professor Yang Liu summarizes recent progress in nonviral nanoparticle approaches for CRISPR/Cas9 delivery.

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