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764612

Sigma-Aldrich

Poly(D,L-lactide)

greener alternative

average Mn 5,000, PDI ≤1.1

Synonym(s):

PDLA, PLA, polyDL-lactide

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About This Item

UNSPSC Code:
12162002
NACRES:
NA.23

form

solid

Quality Level

100

mol wt

average Mn 5,000

greener alternative product characteristics

Design for Energy Efficiency
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

degradation timeframe

<6 months

mp

264-270 °C

PDI

≤1.1

greener alternative category

Enabling

storage temp.

2-8°C

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General description

We are committed to bringing you Greener Alternative Products, which belongs to one of the four categories of greener alternatives. This is an enabling product that belongs to a family of high-performance bio-based polymers that are essential for developing efficient, low-cost, and environmentally friendly renewable energy solutions. Click here for more information.

Application

Used in Drug Delivery including coating nanoparticles. Can be end-group functionalizated or used as a macroinitiator/block precursor.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCL9077
MKCG2488
MKBX5311V
MKBS3411V
MKBL5073

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Wolf, Florian F.; et al.
Macromolecules, 42, 5622-5628 (2009)
Zhang, Wen-Bin; et al.
Macromolecules, 44, 2589-2596 (2011)
Preparation of Protein-Loaded Poly(L-Lactide) Microspheres by Solution-Enhanced Dispersion by Supercritical CO2
Chen A Z, et al.
Journal of Biomimetics, Biomaterials, and Tissue Engineering, 11, 93-100 (2011)

Articles

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Poly(Glycerol Sebacate) in Tissue Engineering and Regenerative Medicine

The world of commercial biomaterials has stagnated over the past 30 years as few materials have successfully transitioned from the bench to clinical use. Synthetic aliphatic polyesters have continued to dominate the field of resorbable biomaterials due to their long history and track record of approval with the U.S. Food and Drug Administration (FDA).

Fabrication of Drug-loaded Microparticles Using Hydrogel Technology and Recent Innovation in Automation

Microparticle drug delivery systems have been extensively researched and applied to a wide variety of pharmaceutical and medical applications due to a number of advantages including injectability, local applicability to target tissues and sites, and controlled drug delivery over a given time period.

Biodegradable Polyester Based Nanoparticle Formation by Miniemulsion Technique

Aliphatic polyesters such as polylactide, poly(lactide-co-glycolide) and polycaprolactone, as well as their copolymers, represent a diverse family of synthetic biodegradable polymers that have been widely explored for medical uses and are commercially available.

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