SML4079
BI-3802
≥98% (HPLC)
Synonym(s):
2‐[(6‐{[5‐Chloro‐2‐(cis-3,5‐dimethylpiperidin‐1‐yl)pyrimidin‐4‐yl]amino}‐1-methyl‐2‐oxo‐1,2‐dihydroquinolin‐3‐yl)oxy]‐N-methylacetamide, BI 3802, BI3802
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About This Item
Empirical Formula (Hill Notation):
C24H29ClN6O3
CAS Number:
Molecular Weight:
484.98
UNSPSC Code:
12352200
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
-10 to -25°C
Biochem/physiol Actions
Potent and selective BCL6 degrader that targets BTB domain with high-affinity.
BI-3802 is a potent and selective BCL6 degrader that targets BTB domain with high-affinity (IC50 ≤3 nM by ULight assay). BI-3802 induces BCL6 polymerization (filaments formation) and SIAH1 E3 ligase-mediated ubiquitination, leading to proteasomal degradation (by 80% post 90 min 5 µM treatment in SU-DHL-4 cells) and inhibition of BCL6-dependent proliferation in a dose-depenent manner (typical dosing range 0.04 - 3 µM).
BI-3802 is a potent and selective BCL6 degrader that targets BTB domain with high-affinity (IC50 ≤3 nM by ULight assay). BI-3802 induces BCL6 polymerization (filaments formation) and SIAH1 E3 ligase-mediated ubiquitination, leading to proteasomal degradation (by 80% post 90 min 5 µM treatment in SU-DHL-4 cells) and inhibition of BCL6-dependent proliferation in a dose-depenent manner (typical dosing range 0.04 - 3 µM).
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