SML3888
Dynapyrazole Compound 20
≥98% (HPLC)
Synonym(s):
6-(3-bromophenoxy)-2- [1-(4-chlorophenyl) cyclopropyl]-7-oxo-4H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile, Compound 20
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About This Item
Empirical Formula (Hill Notation):
C22H14BrClN4O2
Molecular Weight:
481.73
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Dynapyrazole Compound 20 is a potent and selective inhibitor of cytoplasmic S. cerevisiae dynein, an AAA (ATPase associated with diverse cellular activities), which engages the regulatory ATPase sites in the AAA3 and AAA4 domains disrupting allosteric communication across the AAA ring. Ddynapyrazole Compound 20 inhibits dynein’s basal ATPase activity. Also, it inhibits dynein motility by reducing the protein’s ability to bind microtubules.
Potent and selective inhibitor of cytoplasmic S. cerevisiae dynein
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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