SML3024

Isoliensinine

≥98% (HPLC)

• Synonym(s): (+)-Isoliensinine, (1R)-1,2,3,4-Tetrahydro-1-[[4-hydroxy-3-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]phenyl]methyl]-6-methoxy-2-methyl-7-isoquinolinol
• Empirical Formula (Hill Notation): C₃₇H₄₂N₂O₆
• CAS Number: 6817-41-0
• Molecular Weight: 610.74
• MDL number: MFCD11042260
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D 45.0 to 55.0°, c = 0.5 in acetone
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: CN1[C@H](CC(C=C2)=CC=C2OC)C3=C(C=C(C(OC4=C(O)C=CC(C[C@@H]5C(C=C(O)C(OC)=C6)=C6CCN5C)=C4)=C3)OC)CC1
• InChI: 1S/C37H42N2O6/c1-38-15-13-26-20-36(44-5)37(22-29(26)30(38)16-23-6-9-27(42-3)10-7-23)45-35-18-24(8-11-32(35)40)17-31-28-21-33(41)34(43-4)19-25(28)12-14-39(31)2/h6-11,18-22,30-31,40-41H,12-17H2,1-5H3/t30-,31-/m1/s1
• InChI key: AJPXZTKPPINUKN-FIRIVFDPSA-N

Description

Biochem/physiol Actions

Isoliensinine is a major bisbenzylisoquinoline alkaloid found in the seed-embryos of Nelumbo nucifera that exhibits potent anticancer, anti-diabetic and anti-pulmonary fibrosis effects. It induces apoptosis in triple negative breast cancer cells through induction of ROS and p38 MAPK/JNK activation, while showing only mild effects on normal MCF-10A cells. Isoliensinine shows chemosensitizing properties in several cancer cells. It appears that if augments cisplatin uptake int cancer cells.

alkaloid found in the seed-embryos of Nelumbo nucifera that exhibits potent anticancer, anti-diabetic and anti-pulmonary fibrosis effects

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable