Skip to Content
Merck
All Photos(1)

Key Documents

SAB5300177

Sigma-Aldrich

Anti-SOX2 Antibody

mouse monoclonal, 10F10

Synonym(s):

Sox-2, Sox2, lcc, ysb

Sign Into View Organizational & Contract Pricing

Select a Size

All Photos(1)

Select a Size

Change View

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Product Name

Monoclonal Anti-SOX2 antibody produced in mouse, clone 10F10, ascites fluid

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

10F10, monoclonal

mol wt

34 kDa

species reactivity

human

technique(s)

direct ELISA: 1:10,000
immunohistochemistry: 1:200-1:1,000
indirect immunofluorescence: 1:200-1:1,000
western blot: 1:500-1:2,000

General description

SOX2 (sex-determining region Y-box 2) is a transcription factor consisting of 317 amino acids. It has an HMG (high mobility group box) domain and is a critical transcription regulator of normal stem cell. It is located on human chromosome 3q26.3.

Immunogen

Purified recombinant fragment of human SOX2 expressed in E.coli.
Mouse monoclonal antibody raised against SOX2

Application

Monoclonal Anti-SOX2 antibody has been used as a core pluripotency factor to regulate stem cell pluripotency.

Biochem/physiol Actions

SOX2 (sex-determining region Y-box 2) down-regulation reduces the stem cell count, that affects breast cancer cells in initiating tumor progression. It participates in chemoresistance and regular lung cancer therapies. In mouse, SOX2 plays an important role in branching morphogenesis and regulating lung epithelial cell differentiation.

Physical form

Ascitic fluid containing 0.03% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
PM12110682

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Elisabetta Fiacco et al.
Stem cell research, 49, 102049-102049 (2020-10-24)
While Klinefelter Syndrome (KS) has a prevalence of 85-250 per 100,000 born males, patients are typically underdiagnosed due to a subtle phenotype emerging only late during puberty or adulthood. Rare cases of KS carry a mosaic phenotype 47-XXY/46-XY associated to
Proteasome activation enhances stemness and lifespan of human mesenchymal stem cells
Kapetanou, et al.
Free Radical Biology & Medicine, 103, 226-235 (2017)
Maryam Alowaysi et al.
Stem cell research, 49, 102098-102098 (2020-12-01)
Klinefelter Syndrome (KS) is the most common aneuploidy in humans (prevalence: 85-250 per 100,000 born males) and is characterized by one or more supernumerary X-chromosomes (47-XXY, 48-XXXY and 49-XXXXY karyotypes). KS is a multisystemic disorder associated to multiple phenotypic features
SOX2 Is an Oncogene Activated by Recurrent 3q26.3 Amplifications in Human Lung Squamous Cell Carcinomas
Thomas Hussenet
PLoS ONE, 5(1), e8960-e8960 (2010)
Actinomycin D Down-regulates SOX2 Expression and Induces Death in Breast Cancer Stem Cells
Das T, et al.
Anticancer Research, 37(4), 1655-1663 (2017)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service