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Key Documents

SAB4504615

Sigma-Aldrich

Anti-phospho-LATS1/2 (pThr1079/1041) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-WARTS, Anti-wts

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12 EA
$39.60

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12 EA
$39.60

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

$39.60

Please contact Customer Service for Availability

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 126 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

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Gene Information

mouse ... Ccr7(12775)

Gene Information

human ... CCR3(1232)

Gene Information

mouse ... Cd4(12504)

Gene Information

mouse ... Cd8a(12525)

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

biological source

rat

biological source

mouse

biological source

rat

biological source

rat

clone

4B12, monoclonal

clone

5E8, monoclonal

clone

GK1.5, monoclonal

clone

53-6.7, monoclonal

species reactivity

mouse

species reactivity

human

species reactivity

mouse

species reactivity

mouse

General description

Large tumor suppressor kinase 1/ 2 (LATS1/2) is a mammalian homologue of the Drosophila tumor suppressor gene (lats)/warts. LATS1 and LATS2 are encoded by the gene mapped to human chromosomes 6q23-25.1 and 13q11–q12 respectively. hLATS2 is highly expressed in skeletal muscle and heart. LATS1 encodes a putative serine/threonine kinase.

Immunogen

The antiserum was produced against synthesized peptide derived from human LATS1/2 around the phosphorylation site of Thr1079/1041.

Immunogen Range: 1041-1090

Biochem/physiol Actions

Large tumor suppressor kinase 1 (LATS1) and LATS2 are the key kinase constituents of the Hippo pathway. They play a vital role in the regulation of tumor progression and cell cycle, via various mechanisms and signaling pathways. LATS1 acts as a tumor suppressor in cervical cancer by regulating the expression of cyclin E, p27, matrix metalloproteinase 9 (MMP9) and yes-associated protein 1 (YAP). Overexpression of LATS2 leads to the development of acute myeloid leukemia (AML). Therefore, it is considered as a potential therapeutic target for AML treatment.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
118125

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The expression analysis of LATS2 gene in de novo AML patients.
Gholami M
Medical Oncology (Northwood, London, England), 31, 961-961 (2014)
Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts.
Yabuta N
Genomics, 63, 263-270 (2000)
Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma.
Hisaoka M
Laboratory Investigation; a Journal of Technical Methods and Pathology, 82, 1427-1435 (2002)
LATS1 suppresses proliferation and invasion of cervical cancer
Molecular Medicine Reports, 15, 1654-1660 (2017)
Xiehong Liu et al.
Journal of cellular physiology, 234(4), 5117-5133 (2018-09-27)
Heat-shock protein B1 (HSPB1) is a multifunctional protein that protects against oxidative stress; however, its function in antioxidant pathways remains largely unknown. Here, we sought to determine the roles of HSPB1 in H9c2 cells subjected to oxidative stress. Using nonreducing
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