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I7908

Sigma-Aldrich

IL-2 human

≥98% (SDS-PAGE and HPLC), recombinant, expressed in Pichia pastoris, lyophiilized powder, suitable for cell culture

Synonym(s):

IL-2, Interleukin-2, T-cell growth factor

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About This Item

MDL number:
MFCD00165721
UNSPSC Code:
12352202
NACRES:
NA.75

Product Name

Interleukin-2 human, recombinant, expressed in Pichia pastoris, suitable for cell culture

biological source

human

Quality Level

200

recombinant

expressed in Pichia pastoris

Assay

≥98% (SDS-PAGE and HPLC)

form

lyophilized powder

mol wt

predicted mol wt ~15 kDa

packaging

pkg of 10KU

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P60568

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... IL2(3558)

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Application

Interleukin-2 human has been used to assess changes in tumor necrosis factor receptor 1 (TNFR1). It has also been used in TNFR2 expression on Tregs.

Biochem/physiol Actions

Interleukin 2 (IL2) is a pro-inflammatory cytokine. It consists of three subunits, in which the β subunit is important for receptor mediated signaling. IL2 enhances the development of T regulatory cells and plays a crucial role in antitumor immunity.
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

Physical form

Lyophilized from a 0.2 μm filtered solution in 50 mM sodium phosphate buffer, pH 7.0, containing 0.1% human serum albumin per 0.1 mL of cytokine.

Analysis Note

The biological activity is tested in a cell proliferation assay using an IL-2 dependent murine cytotoxic T cell line, CTLL-2.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLCG6987
SLCF8696
SLCF0846
SLCD6497
SLCD0392

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TNFR1 and TNFR2 expression and induction on human Treg cells from type 1 diabetic subjects
Heinrich M, et al.
Antibodies, 4(1), 34-47 (2015)
Polymorphisms and haplotypes of the interleukin 2 gene are associated with an increased risk of gastric cancer. The possible involvement of Helicobacter pylori
Melchiade, et al.
Cytokine, 96 (2017)
The main function of IL-2 is to promote the development of T regulatory cells
Malek, Th, et al.
Journal of Leukocyte Biology, 74(6) (2003)
The IL-2 receptor complex: its structure, function, and target genes
Minami, Y, et al.
Annual Review of Immunology, 11(1) (1993)
Meera V Singh et al.
Journal of leukocyte biology, 109(4), 807-820 (2020-07-15)
In addition to their role in hemostasis, platelets store numerous immunoregulatory molecules such as CD40L, TGFβ, β2-microglobulin, and IL-1β and release them upon activation. Previous studies indicate that activated platelets form transient complexes with monocytes, especially in HIV infected individuals
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