Skip to Content
Merck
All Photos(1)

Key Documents

H1404

Sigma-Aldrich

Hepatocyte Growth Factor human

>95% (SDS-PAGE), recombinant, expressed in Baculovirus infected High-5 cells, lyophilized powder, suitable for cell culture

Synonym(s):

HGF, Hepatopoietin A, Scatter Factor

Sign Into View Organizational & Contract Pricing

Select a Size

250 MG
$512.00

$512.00

Please contact Customer Service for Availability
All Photos(1)

Select a Size

Change View
250 MG
$512.00

About This Item

EC Number:
214-275-1
MDL number:
MFCD00217422
UNSPSC Code:
12352202
NACRES:
NA.77

$512.00

Please contact Customer Service for Availability

Product Name

Hepatocyte Growth Factor human, HGF, recombinant, expressed in Baculovirus infected High-5 cells, suitable for cell culture

biological source

human

Quality Level

200

recombinant

expressed in Baculovirus infected High-5 cells

Assay

>95% (SDS-PAGE)

form

lyophilized powder

potency

1.0-20.0 ng/mL

quality

endotoxin tested

mol wt

~80 kDa

packaging

pkg of 5x5 μg
pkg of 5 μg

Looking for similar products? Visit Product Comparison Guide

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
16677011667600T1610000
Alpha tocopheryl acid succinate United States Pharmacopeia (USP) Reference Standard

1667803

Alpha tocopheryl acid succinate

Alpha Tocopheryl Acetate United States Pharmacopeia (USP) Reference Standard

1667701

Alpha Tocopheryl Acetate

Alpha Tocopherol United States Pharmacopeia (USP) Reference Standard

1667600

Alpha Tocopherol

RRR-α-Tocopheryl hydrogen succinate European Pharmacopoeia (EP) Reference Standard

T1610000

RRR-α-Tocopheryl hydrogen succinate

manufacturer/tradename

USP

manufacturer/tradename

USP

manufacturer/tradename

USP

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

neat

format

neat

API family

tocopherol

API family

tocopherol

API family

tocopherol

API family

tocopherol

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Biochem/physiol Actions

Hepatocyte growth factor (HGF) is a potent mitogen for hepatocytes and a variety of cell types including endothelial and epithelial cells, melanocytes, and keratinocytes. It also mediates epithelial morphogenesis. HGF is the ligand for the tyrosine kinase receptor encoded by the met proto-oncogene.

Other Notes

The NSO-expressed recombinant HGF is greater than 95% heterodimeric HGF. The insect cell line-expressed recombinant HGF is a mixture of single chain HGF (predominant) with some heterodimeric HGF. Single chain HGF and heterodimeric HGF are equally active in in vitro assays.

Physical form

Lyophilized from a 0.2 μm filtered solution in 20 mM NaH2PO4 and 500 mM NaCl, pH 7.0 with 50 μg BSA per 1 μg HGF

Preparation Note

Reconstitute at 50 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin. After reconstitution, this solution can be stored at 2-8 °C for up to one month or at -20 °C to -70 °C for up to three months. Us a manual defrost freezer and avoid repeated freeze-thaw cycles.

Analysis Note

The biological activity is measured by its ability to induce IL-11 secretion by Saos-2 human osieosarcoma cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    SLCG7933
    SLCF4636
    SLCD4440
    SLCC0104
    SLBZ9529

    Don't see the Right Version?

    If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

    Search for a COA

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Masaki Kobayashi et al.
    Biochemical and biophysical research communications, 527(1), 153-161 (2020-05-25)
    MicroRNA (miRNA) plays a pivotal role in cancer biology. Therefore, tumor suppressor (TS) miRNAs are an attractive target for cancer therapy. However, clinical trials have failed due to the difficulties in miRNA delivery, warranting the development of a novel drug
    Ryuichi Tatsumi et al.
    American journal of physiology. Cell physiology, 297(2), C238-C252 (2009-06-12)
    Regenerative coordination and remodeling of the intramuscular motoneuron network and neuromuscular connections are critical for restoring skeletal muscle function and physiological properties. The regulatory mechanisms of such coordination remain unclear, although both attractive and repulsive axon guidance molecules may be
    R A Furlong
    BioEssays : news and reviews in molecular, cellular and developmental biology, 14(9), 613-617 (1992-09-01)
    Hepatocyte growth factor, a potent mitogen for epithelial and other cell types, and scatter factor, a stimulant of epithelial cell motility are identical. In addition to these mitogenic and motogenic functions, the factor has been shown to be an epithelial
    Takanori Takebe et al.
    Nature protocols, 9(2), 396-409 (2014-01-25)
    Generation of functional and vascularized organs from human induced pluripotent stem cells (iPSCs) will facilitate our understanding of human developmental biology and disease modeling, hopefully offering a drug-screening platform and providing novel therapies against end-stage organ failure. Here we describe
    Yingjie Liu et al.
    Development (Cambridge, England), 136(5), 843-853 (2009-01-30)
    Integrin receptors for the extracellular matrix and receptor tyrosine kinase growth factor receptors represent two of the major families of receptors that transduce into cells information about the surrounding environment. Wnt proteins are a major family of signaling molecules that
    View All Related Papers

    Articles

    Hepatocyte Growth Factor (HGF)

    Hepatocyte growth factor (HGF) is a potent mitogen for hepatocytes and a variety of other cells, including endothelial and epithelial cells, melanocytes, and keratinocytes.

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service