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Key Documents

AV48138

Sigma-Aldrich

Anti-PGAM2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-MGC88743, Anti-PGAMM, Anti-Phosphoglycerate mutase 2 (muscle)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

29 kDa

species reactivity

human

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_000281

UniProt accession no.

P15259

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PGAM2(5224)

General description

Phosphoglycerate mutase 2 (muscle) (PGAM2) catalyzes the the conversion of 3-phosphoglycrate to 2-phosphoglycerate during glucolysis. Genetic alterations in PGAM2 have been linked to muscle phosphoglycerate mutase deficiency and Greig cephalopolysyndactyly syndrome.
Rabbit Anti-PGAM2 antibody recognizes human, mouse, rat, zebrafish, and pig PGAM2.

Immunogen

Synthetic peptide directed towards the N terminal region of human PGAM2

Application

Rabbit Anti-PGAM2 antibody is suitable for western blot applications at a concentration of 1μg/ml.

Biochem/physiol Actions

PGAM2 is the interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. It can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.

Sequence

Synthetic peptide located within the following region: MATHRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKM

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
QC18047

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K Wagner et al.
Genomics, 8(3), 487-491 (1990-11-01)
Greig cephalopolysyndactyly syndrome (GCPS) is an autosomal dominant disorder that has been mapped to 7p13. We have investigated two patients with GCPS and a cytogenetically visible microdeletion of the short arm of chromosome 7 with gene probes that have been

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We presents an article about the Warburg effect, and how it is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer cells show an increased dependence on glycolysis to meet their energy needs, regardless of whether they were well-oxygenated or not.

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