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Key Documents

F0290000

Flutrimazole

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole

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About This Item

Empirical Formula (Hill Notation):
C22H16F2N2
CAS Number:
119006-77-8
Molecular Weight:
346.37
MDL number:
MFCD00865591
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

flutrimazole

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Fc1c(cccc1)C([n]4cncc4)(c3ccc(cc3)F)c2ccccc2

InChI

1S/C22H16F2N2/c23-19-12-10-18(11-13-19)22(26-15-14-25-16-26,17-6-2-1-3-7-17)20-8-4-5-9-21(20)24/h1-16H

InChI key

QHMWCHQXCUNUAK-UHFFFAOYSA-N

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Flutrimazole EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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F Van Gerven et al.
Mycoses, 38(9-10), 389-393 (1995-09-01)
Bifonazole, clotrimazole, flutrimazole, ketoconazole, miconazole and sertaconazole were tested for their activity against 23 isolates of Malassezia furfur by agar dilution in vitro. Topical formulations of the same agents were evaluated for efficacy against M. furfur skin infections in guinea
L Conte et al.
Arzneimittel-Forschung, 42(6), 847-853 (1992-06-01)
The percutaneous absorption and skin distribution of a skin cream containing 1% 14C-labelled 1-[(fluorophenyl) (4-fluorophenyl) phenylmethyl]-1H-imidazole (flutrimazole, UR-4056, CAS 119006-77-8) was studied in minipigs. The same dose of flutrimazole was administered i.v. and topically (as a cream) on scarified skin
M L Vericat et al.
Arzneimittel-Forschung, 42(6), 841-846 (1992-06-01)
Studies with 1-[(2-fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H- imidazole (flutrimazole, CAS 119006-77-8), a new topical imidazole antifungal agent, have been carried out to investigate the acute toxicity of the active substance in mice and rats, as well as the acute ocular and dermal irritation in
A del Palacio et al.
Mycoses, 42(11-12), 649-655 (2000-02-19)
In a double-blind, randomized study the efficacy and tolerance of flutrimazole 1% cream were compared with ketoconazole 2% cream, applied once daily for 4 weeks, in 60 patients with culturally proven dermatophytosis (47 patients) or cutaneous candidosis (13 patients). Both
J Pereda et al.
Mycoses, 46(3-4), 126-131 (2003-07-23)
The aim of the study was to compare the efficacy and tolerability of flutrimazole 1% powder vs. bifonazole 1% powder in treating tinea pedis. A multicentre, double blind, randomized, parallel and comparative study was conducted. Two hundred and twenty-two patients
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