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64340

Sigma-Aldrich

DL-Methionine

≥99.0% (NT)

Synonym(s):

(±)-2-Amino-4-(methylmercapto)butyric acid, DL-2-Amino-4-(methylthio)butanoic acid

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100 G
$85.70
500 G
$335.00

About This Item

Linear Formula:
CH3SCH2CH2CH(NH2)COOH
CAS Number:
59-51-8
Molecular Weight:
149.21
Beilstein:
636185
EC Number:
200-432-1
MDL number:
MFCD00063096
UNSPSC Code:
12352209
PubChem Substance ID:
329759959
NACRES:
NA.26

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Product Name

DL-Methionine, ≥99.0% (NT)

Quality Level

200

Assay

≥99.0% (NT)

form

powder or crystals

optical activity

[α]/D, c = 5 in 5 M HCl (inactive)

concentration

5% in 5 M HCl

ign. residue

≤0.05%

color

white

mp

280 °C (dec.) (lit.)

solubility

5 M HCl: 1 g/10 mL, clear, colorless to almost colorless

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1 of 4

This Item
162574403908.00408
Dimethylglyoxime ≥97.0% (TLC)

03858

Dimethylglyoxime

Dimethylglyoxime ACS reagent, ≥99%

162574

Dimethylglyoxime

Dimethylglyoxime puriss. p.a., ACS reagent, for the detection of Ni, ≥99.0% (TLC)

40390

Dimethylglyoxime

Maleic anhydride for synthesis

8.00408

Maleic anhydride

form

powder

form

liquid

form

solid

form

solid

mp

240-241 °C (lit.)

mp

240-241 °C (lit.)

mp

240-241 °C (lit.)

mp

51-53 °C

functional group

amine

functional group

amine, oxime

functional group

amine, oxime

functional group

-

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

Application

DL-Methionine has been used to study the susceptibility of methionine to oxidation during the development of monoclonal antibodies.[1]

Biochem/physiol Actions

Methionine is an essential amino acid which acts a precursor for transmethylation and transsulfuration. In proteins, L-methionine is the biologically active form. D-methionine is converted to L-methionine by enzymes in the body.[2] The adenosylation of methionine results in the formation of S-adenosyl-L-methionine (SAM), which serves as a methyl donor to various substances. L-Methionine′s metabolic product glutathione is known to regulate immune response and has antiviral action.[3]

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
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    Certificates of Analysis (COA)

    Lot/Batch Number
    WXBD4739V
    WXBD4361V
    WXBD4362V
    WXBC9606V
    WXBD2053V

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    L-methionine as immune supportive supplement: a clinical evaluation.
    Van Brummelen and du Toit D
    Amino Acids, 33(1), 157-163 (2007)
    Rapid assessment of oxidation via middle-down LCMS correlates with methionine side-chain solvent-accessible surface area for 121 clinical stage monoclonal antibodies
    Rong Yang
    MAbs (2017)
    Il Jin Cho et al.
    Biochemical and biophysical research communications, 367(1), 190-194 (2008-01-02)
    We investigated the hypolipidemic effect of resveratrol focused on the mRNA expression and hepatic HMG-CoA reductase (HMGR) activity in hamsters fed a high-fat diet. Male Syrian Golden hamsters were fed a high-fat diet containing 0.025% fenofibrate or 0.025% resveratrol for
    Bio-Methionine Production from Glucose - Cost Analysis - Methionine E31A (2016)
    Pilar Lloris-Garcerá et al.
    Journal of molecular biology, 426(11), 2246-2254 (2014-04-03)
    The increasing number of solved membrane protein structures has led to the recognition of a common feature in a large fraction of the small-molecule transporters: inverted repeat structures, formed by two fused homologous membrane domains with opposite orientation in the
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