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MABN1587

Sigma-Aldrich

Anti-MATR3 Antibody, clone 3G1.1

clone 3G1.1, from mouse

Synonym(s):

Matrin-3

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5 MG
$164.00

$164.00

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5 MG
$164.00

About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

$164.00

Please contact Customer Service for Availability
Request a Bulk Order

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

3G1.1, monoclonal

species reactivity

mouse, human

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

isotype

IgG2bκ

NCBI accession no.

NP_001181884

UniProt accession no.

P43243

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This Item
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Ribonuclease A from bovine pancreas 4×cryst., ~70 U/mg (acc. to Kunitz)

83834

Ribonuclease A from bovine pancreas

Ribonuclease A from bovine pancreas Type X-A, ≥90% (SDS-PAGE), ≥70 Kunitz units/mg protein

R5250

Ribonuclease A from bovine pancreas

Ribonuclease A from bovine pancreas Type II-A, ≥60% (SDS-PAGE), >= 60 Kunitz units/mg protein

R5000

Ribonuclease A from bovine pancreas

Ribonuclease A from bovine pancreas Type III-A, ≥85% RNase A basis (SDS-PAGE), 85-140 Kunitz units/mg protein

R5125

Ribonuclease A from bovine pancreas

form

powder

form

buffered aqueous solution

form

solid

form

lyophilized powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

shipped in

wet ice

shipped in

-

shipped in

-

shipped in

-

mol wt

~13,700, Mr ~13700

mol wt

~13,700

mol wt

~13,700

mol wt

~13,700

impurities

proteases, none detected

impurities

-

impurities

salt, essentially free

impurities

salt, essentially free

General description

Matrin-3 (UniProt P43243) is encoded by the MATR3 (also known as ALS21, KIAA0723, VCPDM) gene (Gene ID 9782) in human. Matrin-3 is an inner nuclear matrix protein involved in multiple nuclear processes, including DNA double strand break response, DNA replication/repair, chromatin organization, and RNA stability and processing. Matrin-3 contains two RNA recognition motifs (a.a. 398-473/RRM1 and a.a. 496-571/RRM2) that mediate RNA-binding and a DNA-binding zinc finger motif (a.a. 801-832). Matrin-3 is known to interact with the RNA-binding protein TDP-43 and MATR3 gene mutations are linked to amyotrophic lateral sclerosis (ALS). Matrin-3 is also a known target of multiple alpha herpes viruses and is known to be utilized by HIV-1 as a Rev cofactor.

Specificity

Expected to react with both spliced isoforms of human MATR3 reported by UniProt (P43243).

Immunogen

GST-tagged recombinant internal fragment from the N-terminal half of human martin-3.

Application

Immunohistochemistry Analysis: An 1:250 dilution from a representative lot detected MATR3 in human cerebellum, human small intestine, and mouse cerebral cortex tissue sections.
This Anti-MATR3 Antibody, clone 3G1.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of MATR3.

Quality

Evaluated by Western Blotting in SHSY-5Y cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected MATR3 in 10 µg of SHSY-5Y cell lysate.

Target description

~110 kDa observed. 94.62 kDa (isoform 1) and 62.58 kDa (isoform 2) calculated. The detected band size is consistent with the reported apparent molecular weight (Nakayasu, H., and Berezney, R. (1991). Proc. Natl. Acad. Sci. U. S. A. 88(22):10312-10316).

Physical form

Format: Purified

Other Notes

Concentration: Please refer to lot specific datasheet.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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