8.53075
Boc-Gln(Trt)-OH
Novabiochem®
Synonym(s):
Boc-Gln(Trt)-OH, N-α-t.-Boc-γ-trityl-L-glutamine
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About This Item
Empirical Formula (Hill Notation):
C29H32N2O5
CAS Number:
Molecular Weight:
488.57
MDL number:
UNSPSC Code:
12352209
NACRES:
NA.22
Recommended Products
Quality Level
product line
Novabiochem®
Assay
≥98% (TLC)
form
powder
reaction suitability
reaction type: Boc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
functional group
amide
storage temp.
15-25°C
SMILES string
N([C@@H](CCC(=O)NC(c3ccccc3)(c2ccccc2)c1ccccc1)C(=O)O)C(=O)OC(C)(C)C
General description
A trityl-protected derivative which increases the solubility of glutamine during the coupling step in SPPS [1]. Its use gives higher yields and lower by-product formation. During the following coupling cycles the temporary side-chain protection is removed.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Boc SPPS
Literature references
[1] P. Sieber, et al. (1991) Tetrahedron Lett., 32, 739.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Boc SPPS
Literature references
[1] P. Sieber, et al. (1991) Tetrahedron Lett., 32, 739.
Linkage
Replaces: 04-12-0188
Analysis Note
Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in methanol): -3.0 - -2.0 °
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (1 mmole in 2 ml DMF): clear solution
To see the solvent systems used for TLC of Novabiochem® products please click here.
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in methanol): -3.0 - -2.0 °
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (1 mmole in 2 ml DMF): clear solution
To see the solvent systems used for TLC of Novabiochem® products please click here.
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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