1.02408

Tris(hydroxymethyl)aminomethane

volumetric standard, secondary reference material for acidimetry, traceable to NIST Standard Reference Material (SRM) Certipur^® Reag. Ph Eur,Reag. USP

• Synonym(s): Tris Base, Tris(hydroxymethyl)aminomethane, 2-Amino-2-(hydroxymethyl)-1,3-propanediol, THAM, Tris base, Trometamol
• Linear Formula: NH₂C(CH₂OH)₃
• CAS Number: 77-86-1
• Molecular Weight: 121.14
• Beilstein: 741883
• MDL number: MFCD00004679
• UNSPSC Code: 41116107
• EC Index Number: 201-064-4
• NACRES: NA.24

Properties

• Agency: ISO 17025; reag. Ph. Eur.; reag. USP
• Quality Level: 300
• vapor pressure: 0.0267 hPa ( 20 °C)
• product line: Certipur^®
• form: solid
• potency: >5000 mg/kg LD₅₀, oral (Rat); >5000 mg/kg LD₅₀, skin (Rat)
• technique(s): titration: suitable
• pH: 10.2-10.6 (20 °C, 6 g/L in H₂O)
• useful pH range: 7-9
• pKa (25 °C): 8.1
• bp: 219-220 °C/10 mmHg (lit.); 219-220 °C/13.3 hPa
• mp: 167-172 °C (lit.)
• solubility: 678 g/L
• density: 1.35 g/cm³ at 23 °C
• bulk density: 840 kg/m³
• storage temp.: 15-25°C
• SMILES string: NC(CO)(CO)CO
• InChI: 1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
• InChI key: LENZDBCJOHFCAS-UHFFFAOYSA-N

Description

General description

Tris(hydroxymethyl)aminomethane is a volumetric standard manufactured under rigorous conditions and measured with the highest possible precision. Its mass fraction is determined by potentiometric titration, and it is qualified in a DIN EN ISO/IEC 17025 accredited laboratory.

Please visit ISO certificates and Site Quality Self-Assessments to access the current certificates of accreditation.

Download your certificate at http://www.sigma-aldrich.com to view certified values, including uncertainty and expiry date.

Application

It finds its use as a certified reference material (CRM) for the standardization of volumetric solutions in acidimetric titrations, according to USP and Ph. Eur.

Features and Benefits

• Available as a solid in a secure glass bottle to ensure its stability for the entire shelf life until opened.
• Certified reference material according to ISO 17034
• High-purity material traceable to NIST SRMs
• Qualified in a DIN EN ISO/IEC 17025 accredited laboratory
• In accordance with the chapter reagents of USP and Ph. Eur
• High-quality offering accurate titer determinations
• Accompanied by a certificate of analysis (CoA)

Packaging

SKU-pack size numbers ending with a "3" are SmartChemicals with an RFID tag on the label for seamless data transfer to the instrument, e.g. xxxxxx1003 or xxxxxxx 4003. More information on www.sigmaaldrich.com/SmartChemicals

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Legal Information

CERTIPUR is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable