SML4035

CGP 78608 hydrochloride

≥97%

• Synonym(s): CGP 78608 hydrochloride, CGP-78608 hydrochloride, CGP78608 hydrochloride, PAMQX hydrochloride, [(1S)-1-[[(7-Bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]amino]ethyl]phosphonate, hydrochloride, P-[(1S)-1-[[(7-Bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]amino]ethyl]phosphonic acid, hydrochloride (1:1)
• Empirical Formula (Hill Notation): C₁₁H₁₃BrN₃O₅P·HCl
• CAS Number: 1135278-54-4
• Molecular Weight: 414.58
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥97%
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: -10 to -25°C

Description

Biochem/physiol Actions

Potent glycine site-selective NMDA receptor antagonist with anticonvulsant efficacy in vivo.
CGP 78608 (PAMQX) is a potent glycine site-selective NMDA receptor antagonist (IC50 = 5 nM by competitive binding against 5 nM [3H]MDL 105,519; IC50 = 3/2.7 μM against AMPA/kainate, >10 μM against CGP39653 (glutamate site) and channel blocker MK-801) that exhibits anticonvulsant efficacy in mice in vivo (electroshock-induced convulsion ED50 = 12 mg/kg i.p.).

Caution

Hygroscopic