SML3748

TH10785

≥98% (HPLC)

• Synonym(s): N-Cyclohexyl-2-cyclopropyl-4-quinazolinamine, NN-Cyclohexyl-2-cyclopropylquinazolin-4-amine, TH 10785, TH-10785, V028-5832
• Empirical Formula (Hill Notation): C₁₇H₂₁N₃
• CAS Number: 1002801-51-5
• Molecular Weight: 267.37
• UNSPSC Code: 12352200
• NACRES: NA.21

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• SMILES string: C1(N=C(C2CC2)N=C3NC4CCCCC4)=C3C=CC=C1
• InChI key: ZQMGQZOHIDOPCQ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

8-oxoG DNA glycosylase OGG1 activator that induced β,δ-lyase activity for polynucleotide kinase phosphatase (PNKP1)-dependent base excision repair (BER).

TH10785 is an 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1) activator that interats with OGG1 via Phe319 and Gly42, causing increased OGG1 recruitment to cellular oxidative DNA damage sites (by 1.37-fold post 20 sec 1 µM treatment; U2OS). TH10785-activated OGG1 recognizes not only 8-oxoG, but also apurinic/apyrimidinic (AP, abasic) sites with a higher efficiency due to a newly induced β,δ-lyase enzymatic activity that generates base excision repair (BER) intermediates that require polynucleotide kinase phosphatase (PNKP1) instead of apurinic endonuclease 1 (APE1) for completing the repair.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable