SML3725

Icotinib

≥98% (HPLC)

• Synonym(s): (3-Ethynyl-phenyl)(7,8,10,11,13,14-hexahydro-6,9,12,15-tetraoxa-1,3-diazacyclododeca[b]naphthalen-4-yl)-amine, 4-[(3-Ethynylphenyl)amino]-6,7-benzo-12-crown-4-quinazoline, BPI 2009, BPI 2009H free base, BPI-2009, BPI-2009H free base, BPI2009, BPI2009H free base, Conmana
• Empirical Formula (Hill Notation): C₂₂H₂₁N₃O₄
• CAS Number: 610798-31-7
• Molecular Weight: 391.42
• MDL number: MFCD22124501
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: N(c4cc(ccc4)C#C)c1ncnc2c1cc3c(c2)OCCOCCOCCO3
• InChI key: QQLKULDARVNMAL-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Icotinib is an orally active, potent and highly selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (IC50 = 5 nM) that inhibits EGFR-mediated intracellular tyrosine phosphorylation (IC50 = 45 nM; A431 cells) and cancer proliferation in cultures (A431/BGC-823 IC50 = 1.0/4.1 μM) and in vivo (30-120 mg/kg via daily p.o. to mice with A431, A549, H460 and HCT8 xenografts).

Orally active, potent and highly selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor with anti-cancer efficacy in vitro and in vivo.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable