SML3525

V-9302

≥98% (HPLC)

• Synonym(s): (2S)-2-Amino-4-[bis[[2-[(3-methylphenyl)methoxy]phenyl]methyl]amino]-butanoic acid
• Empirical Formula (Hill Notation): C₃₄H₃₈N₂O₄
• CAS Number: 1855871-76-9
• Molecular Weight: 538.68
• MDL number: MFCD32062750
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• SMILES string: CC1=CC=CC(COC2=C(C=CC=C2)CN(CC3=CC=CC=C3OCC4=CC=CC(C)=C4)CC[C@@H](C(O)=O)N)=C1
• InChI: 1S/C34H38N2O4/c1-25-9-7-11-27(19-25)23-39-32-15-5-3-13-29(32)21-36(18-17-31(35)34(37)38)22-30-14-4-6-16-33(30)40-24-28-12-8-10-26(2)20-28/h3-16,19-20,31H,17-18,21-24,35H2,1-2H3,(H,37,38)/t31-/m0/s1
• InChI key: YGKNVAAMULVFNN-HKBQPEDESA-N

Description

Biochem/physiol Actions

Competitive antagonist of the amino acid transporter ASCT2 (SLC1A5) with anti-tumor activity

V-9302 is a selective competitive antagonist of the amino acid transporter ASCT2 (SLC1A5) with anti-tumor activity. V-9302 caused reduced cellular viability and increased cell death in a panel of cancer cell lines and reduced tumor cell growth in both HCT-116 and HT29 (Fig. 5f) xenograft models.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable