SML3354

NRD167

≥98% (HPLC)

• Synonym(s): Ethyl-(5S,8S)-5-((1H-indol-3-yl)methyl)-8-(((benzyloxy)carbonyl)amino)-2-methyl-4,7-dioxo-14-thioxo-3,6,13,15-tetraazaoctadecan-18-oate
• Empirical Formula (Hill Notation): C₃₄H₄₆N₆O₆S
• CAS Number: 2166487-23-4
• Molecular Weight: 666.83
• MDL number: MFCD34593624
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Description

Biochem/physiol Actions

Ethylester prodrug of a potent and selective sirtuin 5 (SIRT5) inhibitor against SIRT5-dependent cancer proliferation and survival.

RD167 is the ethylester prodrug of a potent and selective sirtuin 5 (SIRT5) inhibitor (IC50 = 370 nM; <10% inhibition of SIRT1/2/3/6 at 10 μM). NRD167 exhibits anti-proliferation (IC50 = 5-8 μM) and apoptosis-induction efficacy (>80% at 5-8 μM) against SIRT5-dependent, but not SIRT5-independent cells. NRD167 selectively impairs proliferation of AML, but not normal hematological progenitors (6.25-12.5 μM; CD34+ cells). Pretreatment of AML patients-derived cells by NRD167 (12.5-25 μM for 72 hrs) prior to xenograft greatly prevents the survival of injected mice.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable