SAB4702109

Monoclonal Anti-CD41/CD61 (PAC-1 epitope) FITC produced in mouse

• Synonym(s): GP3A, GPIIb, GPalpha IIb, GT, Integrin alpha-Iib, platelet GPIIIa, platelet GPIIb
• UNSPSC Code: 12352203

Properties

• conjugate: FITC conjugate
• Quality Level: 100
• antibody product type: primary antibodies
• clone: PAC-1, monoclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): flow cytometry: suitable
• isotype: IgMκ
• storage temp.: 2-8°C
• target post-translational modification: unmodified

Description

General description

CD41 (platelet glycoprotein IIb, integrin alpha IIb) is composed of two subunits (120 kDa transmembrane alpha chain and 23 kDa extracellular beta chain) and interacts with CD61 (platelet glycoprotein IIIa, integrin beta 3) in the presence of calcium to form a functional adhesive protein receptor. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin, and it is involved in platelet aggregation.

Specificity

The mouse monoclonal antibody PAC-1 recognizes an extracellular activation-induced conformational epitope PAC-1 on CD41/CD61 complex (gpIIb/IIIa), also known as integrin alpha IIb beta 3, a receptor which mediates platelet aggregation.

Immunogen

Human platelets

Physical form

Stabilizing Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Preparation Note

Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Storage and Stability

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Other Notes

The antibody solution should be gently mixed before use.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable