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Merck
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주요 문서

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1445470

USP

Mometasone furoate

United States Pharmacopeia (USP) Reference Standard

동의어(들):

(11β,16α)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C27H30Cl2O6
CAS Number:
83919-23-7
Molecular Weight:
521.43
MDL number:
MFCD00866003
UNSPSC 코드:
41116107
PubChem Substance ID:
329750487
NACRES:
NA.24

Grade

pharmaceutical primary standard

API family

mometasone

제조업체/상표

USP

응용 분야

pharmaceutical (small molecule)

형식

neat

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c5ccco5)C(=O)CCl

InChI

1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1

InChI key

WOFMFGQZHJDGCX-ZULDAHANSA-N

유전자 정보

human ... NR3C1(2908)

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관련 카테고리

일반 설명

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

애플리케이션

Mometasone furoate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

생화학적/생리학적 작용

Mometasone furoate is an anti-inflammatory glucocorticoid.

분석 메모

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

기타 정보

Sales restrictions may apply.

픽토그램

Health hazard
GHS08

신호어

Danger

유해 및 위험 성명서

H360D

Hazard Classifications

Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

I Haj-Salem et al.
Allergy, 70(2), 212-219 (2014-12-03)
Allergic asthma is characterized by inflammation and airway remodeling. Bronchial epithelium is considered a key player in coordinating airway wall remodeling. In mild asthma, the epithelium is damaged and fails to proliferate and to repair, whereas in severe asthma, the
William E Berger
Expert review of respiratory medicine, 5(6), 739-746 (2011-11-16)
Mometasone furoate and formoterol fumarate dihydrate (MF/F) administered via metered-dose inhaler with a dose counter is a new fixed-dose combination of an inhaled corticosteroid and a long-acting β2-agonist indicated for daily maintenance therapy in patients aged ≥12 years with persistent
Jill P Karpel et al.
Current medical research and opinion, 23(11), 2897-2911 (2007-10-10)
Mometasone furoate (MF), a potent synthetic inhaled corticosteroid (ICS) with a high affinity for the glucocorticoid receptor, is approved for use in the treatment of asthma. Publications reviewed in this article were identified via searches of MEDLINE and EMBASE databases
Kelli Hart et al.
Respirology (Carlton, Vic.), 14(8), 1166-1172 (2009-10-13)
To examine the evidence for the efficacy of once daily dosing of mometasone furoate (MF) and to establish the dose-response relationship for MF in asthma. Meta-analysis of double-blind, randomized controlled clinical trials, identified through a Medline and EMBASE search, comparing
Günther Hochhaus
Clinical therapeutics, 30(1), 1-13 (2008-03-18)
Mometasone furoate nasal spray (MFNS) is recommended as a first-line therapy for allergic rhinitis. The purpose of intranasal administration is to deliver maximally effective therapy to the affected nasal tissues while minimizing systemic exposure. This article reviews the pharmacokinetic and
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