W1020

W146 hydrate

≥98% (HPLC)

• 동의어(들): ML056, R-3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid hydrate, [(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid
• 실험식(Hill 표기법): C₁₆H₂₇N₂O₄P · xH₂O
• CAS Number: 909725-61-7
• Molecular Weight: 342.37 (anhydrous basis)
• MDL number: MFCD16875441
• UNSPSC 코드: 12352211
• PubChem Substance ID: 329830425
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: off-white
• solubility: methanol: soluble (with 0.1% TFA)
• 주관자: Novartis
• 저장 온도: 2-8°C
• SMILES string: O.CCCCCCc1cccc(NC(=O)[C@H](N)CCP(O)(O)=O)c1
• InChI: 1S/C16H27N2O4P.H2O/c1-2-3-4-5-7-13-8-6-9-14(12-13)18-16(19)15(17)10-11-23(20,21)22;/h6,8-9,12,15H,2-5,7,10-11,17H2,1H3,(H,18,19)(H2,20,21,22);1H2/t15-;/m1./s1
• InChI key: DQKSZHVSROOTFY-XFULWGLBSA-N

설명

일반 설명

W146 hydrate functions as an orthosteric antagonist. It is associated with blood lymphopenia and lung edema in mice.

애플리케이션

W146 hydrate has been used to assess vascular permeability in mice.

생화학적/생리학적 작용

Potent S1P(1) competitive antagonist; Ki = 10-77 nM.

특징 및 장점

This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable