T2067

Tyrphostin AG 879

99% (HPLC)

• 동의어(들): α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide
• 실험식(Hill 표기법): C₁₈H₂₄N₂OS
• CAS Number: 148741-30-4
• Molecular Weight: 316.46
• MDL number: MFCD00236450
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278728
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: 99% (HPLC)
• solubility: DMSO: soluble (at 26 mg/ml); H₂O: insoluble
• SMILES string: CC(C)(C)c1cc(\C=C(/C#N)C(N)=S)cc(c1O)C(C)(C)C
• InChI: 1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,21H,1-6H3,(H2,20,22)/b12-7+
• InChI key: XRZYELWZLNAXGE-KPKJPENVSA-N
• 유전자 정보: human ... ERBB2(2064) , NTRK1(4914)

설명

애플리케이션

Tyrphostin AG 879 (AG879) has been used for studying its effect on ErbB2 receptor phosphorylation in A431 cells. This study reported that AG879 at 10 muM can cause 15% inhibition of receptor phosphorylation¹. AG879 has also been used as a neurotrophic tyrosine kinase receptor inhibitor to study the disruption of Sertoli cell aggregation².

생화학적/생리학적 작용

Inhibits the tyrosine kinase activity of the nerve growth factor receptor (TrkA; pp140trk) and heregulin receptor erbB-2 (HER-2).

Tyrphostin AG 879 is known to block RAF-1 and Her-2 expression and exhibit anticancer functions in breast cancer cells³. Furthermore, AG879 is known to block ETK1-PAK1 interactions and the growth of RAS-induced sarcomas in nude mice⁴.

특징 및 장점

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제조 메모

Tyrphostin AG 879 is soluble in DMSO at 26/ml and is insoluble in water.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)