T0535

Tolfenamic acid

NSAID

• 동의어(들): 2 (3-Chloro-2-methylanilino)benzoic acid, 2-([3-Chloro-2-methylphenyl]amino)benzoic acid
• 실험식(Hill 표기법): C₁₄H₁₂ClNO₂
• CAS Number: 13710-19-5
• Molecular Weight: 261.70
• EC Number: 237-264-3
• MDL number: MFCD00133865
• UNSPSC 코드: 12352202
• PubChem Substance ID: 24899896
• NACRES: NA.77

속성

• Quality Level: 200
• 분석: ≥98% (TLC)
• 양식: powder
• solubility: ethanol: 50 mg/mL, clear, greenish-yellow
• SMILES string: Cc1c(Cl)cccc1Nc2ccccc2C(O)=O
• InChI: 1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18)
• InChI key: YEZNLOUZAIOMLT-UHFFFAOYSA-N

설명

일반 설명

Tolfenamic acid is a fenamate and is made up of a monocarboxylate diphenylamine nucleus.

애플리케이션

Tolfenamic acid has been used in Arabidopsis bud assay for activity comparison with quinazolinedione derivatives (QADD) based compounds.

생화학적/생리학적 작용

Non-steroidal anti-inflammatory agent. Interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor.

Tolfenamic acid is involved in the inhibition of prostaglandin synthesis. It also plays a role in apoptosis of head and neck cancer cells.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves