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Merck
모든 사진(1)

주요 문서

SRP5187

Sigma-Aldrich

HSD17B10, GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

동의어(들):

17b-HSD10, ABAD, ERAB, HADH2, HCD2, MHBD, SCHAD

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About This Item

CAS Number:
UNSPSC 코드:
12352202
NACRES:
NA.32

생물학적 소스

human

재조합

expressed in baculovirus infected Sf9 cells

분석

≥70% (SDS-PAGE)

양식

buffered aqueous glycerol solution

분자량

~51 kDa

NCBI 수납 번호

응용 분야

cell analysis

배송 상태

dry ice

저장 온도

−70°C

유전자 정보

human ... HSD17B10(3028)

일반 설명

HSD17B10 gene encodes the protein 17-beta-hydroxysteroid dehydrogenase 10 that is a member of the short-chain dehydrogenase/reductase superfamily SCHAD. HSD17B10 gene product is a mitochondrial protein that is involved in lipid metabolism, fatty acid oxidation and steroid hormone metabolism. HSD17B10 protein has been implicated in the development of Alzheimer′s disease and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Furthermore, HSD17B10 may act as a direct molecular link between beta-amyloid and mitochondrial toxicity.

물리적 형태

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

제조 메모

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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문서 라이브러리 방문

Joyce W Lustbader et al.
Science (New York, N.Y.), 304(5669), 448-452 (2004-04-17)
Mitochondrial dysfunction is a hallmark of beta-amyloid (Abeta)-induced neuronal toxicity in Alzheimer's disease (AD). Here, we demonstrate that Abeta-binding alcohol dehydrogenase (ABAD) is a direct molecular link from Abeta to mitochondrial toxicity. Abeta interacts with ABAD in the mitochondria of
Song-Yu Yang et al.
Trends in endocrinology and metabolism: TEM, 16(4), 167-175 (2005-04-30)
Human 17beta-hydroxysteroid dehydrogenase type 10 (17beta-HSD10) is a mitochondrial enzyme encoded by the SCHAD gene, which escapes chromosome X inactivation. 17Beta-HSD10/SCHAD mutations cause a spectrum of clinical conditions, from mild mental retardation to progressive infantile neurodegeneration. 17Beta-HSD10/SCHAD is essential for

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