추천 제품
생물학적 소스
human
재조합
expressed in CHO cells
분석
≥95% (HPLC)
≥95% (SDS-PAGE)
양식
lyophilized
효능
≤5.0 ng/mL ED50
분자량
37.9 kDa
포장
pkg of 20 μg
기술
cell culture | mammalian: suitable
불순물
<1 EU/μg endotoxin, tested
색상
white to off-white
적합성
suitable for molecular biology
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... IL6R(3570)
일반 설명
Interleukin-6 (IL-6) mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6Rα and gp130. The IL-6Rα chain is the binding component specific to IL-6; while the gp130 only transmits signals of IL-6 when bound to IL-6Rα. IL-6R has a role in various signaling cascades. The gp130 also can transmit signals from leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), interleukin-11 (IL-11) and cardiotrophin-1 (CT-1) in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6Rα alone. IL-6Rα is expressed in a wide range of cells including T cells, fibroblasts and macrophages. Soluble IL-6Rα which consists of only the extracellular domain of the IL-6Rα chain, acts as an agonist of IL-6 activity at low concentrations. Recombinant human sIL-6Rα is a 37.6kDa protein consisting of the extracellular domain of the IL-6Rα chain (339 amino acid residues).
Research Area: IMMUNO AND CKS
Interleukin-6 Receptor Alpha (IL-6Rα) is a transmembrane protein.
Interleukin-6 Receptor Alpha (IL-6Rα) is a transmembrane protein.
애플리케이션
sIL-6 Receptor alpha human has been used in cell culture to treat fibroblasts. It has also been used in stimulation experiments to analyze IL-6 trans-signaling.
생화학적/생리학적 작용
Interleukin-6 Receptor Alpha (IL-6Rα) plays a dual role in signaling. In classical signaling, it interacts with glycoprotein 130 to promote the anti-inflammatory and regenerative effects of IL-6. In contrast, during trans-signaling, it facilitates the pro-inflammatory effects of IL-6 by allowing cells lacking IL-6Rα to respond to IL-6 in the presence of soluble IL-6Rα. IL-6Rα exists in both soluble and transmembrane forms. The transmembrane form is integrated into the cell membrane of target cells. IL-6 and the IL-6 receptor alpha chain (IL-6R) are expressed by various cell types, including monocytes, lymphocytes, fibroblasts, and endothelial cells.
서열
LAPRRCPAQE VARGVLTSLP GDSVTLTCPG VEPEDNATVH WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH DSGNYSCYRA GRPAGTVHLL VDVPPEEPQL SCFRKSPLSN VVCEWGPRST PSLTTKAVLL VRKFQNSPAE DFQEPCQYSQ ESQKFSCQLA VPEGDSSFYI VSMCVASSVG SKFSKTQTFQ GCGILQPDPP ANITVTAVAR NPRWLSVTWQ DPHSWNSSFY RLRFELRYRA ERSKTFTTWM VKDLQHHCVI HDAWSGLRHV VQLRAQEEFG QGEWSEWSPE AMGTPWTESR SPPAENEVST PMQALTTNKD DDNILFRDSA NATSLPVQD
물리적 형태
Lyophilized powder.
재구성
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Hibi, M., et al.
Cytokine Reference, 1761-1773 (2001)
CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium.
Li R
PLoS ONE, 6(9), e23148-e23148 (2011)
Interleukin-6 Receptor Polymorphisms Contribute to the Neurological Status of Korean Patients with Ischemic Stroke.
Kim DH
Journal of Korean Medical Science, 31(3), 430-434 (2016)
T Sugita et al.
The Journal of experimental medicine, 171(6), 2001-2009 (1990-06-01)
Two species of the cDNAs encoding murine IL-6-R (one is abnormal and the other authentic) have been cloned from a plasmacytoma cell line, P3U1, and BALB/c mouse spleen cDNA libraries. In the cDNA encoding the abnormal IL-6-R, the region corresponding
Felix Yemanyi et al.
Investigative ophthalmology & visual science, 61(13), 29-29 (2020-11-21)
Lysophosphatidic acid (LPA) and soluble interleukin-6 receptor (sIL6R) are elevated in primary open angle glaucoma (POAG). LPA and IL6 modulate in response to biomechanical stimuli and converge on similar fibrotic phenotypes. Thus, we determined whether LPA and IL6 trans-signaling (IL6/sIL6R)
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