SRP0570

5′-NUCLEOTIDASE/CD73, His-Tag

recombinant, expressed in HEK 293 cells

• 동의어(들): 5′- nucleotidase, Ecto-5′-nucleotidase
• UNSPSC 코드: 12352202
• NACRES: NA.26

속성

• 재조합: expressed in HEK 293 cells
• 양식: frozen liquid
• 분자량: 58.6 kDa
• UniProt 수납 번호: P21589
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... NT5E(4907)

설명

일반 설명

5′-Nucleotidase/CD73 is glycosyl-phosphatidyl inositol (GPI)- anchored cell surface protein. Itis present in various tissues and cells including endothelial cells, epithelialcells, and subsets of B and T cells.

애플리케이션

5′-Nucleotidase/CD73 has been used as a standard in recombinanthuman CD73 assay.

생화학적/생리학적 작용

5′-Nucleotidase/CD73 actsas a rate-limiting enzyme to produce adenosine. It helps in upholding tissuehomeostasis by converting the adenosine triphosphate (ATP)-triggered immuneactivation to adenosine-mediated immunosuppression.CD73 is a novel immunoinhibitory protein that participates in tumor growthand metastasis. CD73 in combination with conventional therapy and/or otherimmune checkpoint inhibitors has been reported to show therapeutic effectsagainst cancer.

물리적 형태

Aqueous solution

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319
• 예방조치 성명서: P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable