추천 제품
생물학적 소스
human
재조합
expressed in FreeStyle™ 293-F cells
분석
≥86% (SDS-PAGE)
양식
aqueous solution
분자량
85 kDa
포장
pkg of 10 μg
저장 조건
avoid repeated freeze/thaw cycles
농도
0.23 mg/mL
NCBI 수납 번호
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
human ... LOXL2(4017)
관련 카테고리
일반 설명
Human LOXL2 (GenBank Accession No. NM_002318), amino acids 26 – 774 (end) with C-terminal His tag, MW = 85 kDa, expressed in FreeStyle 293-F cells.
Lysyl oxidase like 2 (LOXL2) is part of the LOX family of proteins. It is widely expressed. The gene encoding this protein is localized on human chromosome 8p21.3. It has a conserved carboxy-terminal region with a catalytic function and a divergent amino-terminal region.
생화학적/생리학적 작용
Lysyl oxidase like 2 (LOXL2) is an amino oxidase. LOXL2 is involved in various cellular events such as gene transcription, cell migration, adhesion and differentiation. The protein has a role in connecting collagen and/or elastin in the extracellular matrix. It deaminates trimethylated lysine 4 in histone H3, causing transcriptional repression. LOXL2 suppresses some TFIID (transcription factor IID)-associated genes by oxidising methylated TAF10 (TATA-box binding protein associated factor 10). The LOXL2 gene is upregulated in various cancers, such as gastric cancer, breast cancer and squamous cell carcinomas. The gene is associated with cancer cell invasion and lymph node metastasis.
물리적 형태
Formulated in 8 mM PBS, pH 7.4, 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, and 20% glycerol.
법적 정보
FreeStyle is a trademark of Invitrogen Corp.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
Tumor-suppressive microRNA-29 family inhibits cancer cell migration and invasion directly targeting LOXL2 in lung squamous cell carcinoma
Keiko Mizuno
International Journal of Oncology, 48(2), 450-460 (2016)
Tumour-suppressive microRNA-29s directly regulate LOXL2 expression and inhibit cancer cell migration and invasion in renal cell carcinoma.
Nishikawa R
Febs Letters, 589(16), 2136-2145 (2015)
Debika Mitra et al.
Biotechnology journal, 14(3), e1700763-e1700763 (2018-07-28)
Lysyl oxidase (LOX)-mediated collagen crosslinking can regulate osteoblastic phenotype and enhance mechanical properties of tissues, both areas of interest in bone tissue engineering. The objective of this study is to investigate the effect of lysyl oxidase-like 2 (LOXL2) on osteogenic
Verena Aumiller et al.
Scientific reports, 7(1), 149-149 (2017-03-10)
Extracellular matrix (ECM) composition and stiffness are major driving forces for the development and persistence of fibrotic diseases. Lysyl oxidase (LOX) and LOX-like (LOXL) proteins play crucial roles in ECM remodeling due to their collagen crosslinking and intracellular functions. Here
The function and mechanisms of action of LOXL2 in cancer (Review)
Linghong Wu and Ying Zhu
International Journal of Molecular Medicine, 1200-1204 (2015)
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