SML4090

TH-Z93

≥98% (HPLC)

• 동의어(들): (((4-(Hexyloxy)pyridin-2-yl)amino)methylene)bis(phosphonic acid), P,P′-[[[4-(Hexyloxy)-2-pyridinyl]amino]methylene]bis[phosphonic acid]
• 실험식(Hill 표기법): C₁₂H₂₂N₂O₇P₂
• CAS Number: 2260887-09-8
• Molecular Weight: 368.26
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: soluble (H2O + 1 drop 5M NaOH, 2 mg/mL, clear)
• 저장 온도: 2-8°C

설명

생화학적/생리학적 작용

Potent mevalonate (MVA) pathway farnesyl diphosphate synthase (FPPS) inhibitor that stimulates immune responses in vivo.


TH-Z93 is a potent farnesyl diphosphate synthase (FPPS) inhibitor (IC50 = 90 nM) that stimulates immune responses by blocking the mevalonate (MVA) pathway-mediated post-translational protein geranylgeranylation. When co-administered with antigen in mice in vivo, TH-Z93 triggers strong adjuvant responses, increasing OVA-specific antibody titres (in mice immunized with 100 μg OVA + 100 μg TH-Z93) and protects against death caused by live influenza virus PR8 challenge (in mice immunized with 5 μg PR8 HA1 subunit containing TH-Z93). TH-Z93 adjuvant efficacy is blocked by GGPP and synergized with HMG-CoA inhibitor simvastatin.