SML4079

BI-3802

≥98% (HPLC)

• 동의어(들): 2‐[(6‐{[5‐Chloro‐2‐(cis-3,5‐dimethylpiperidin‐1‐yl)pyrimidin‐4‐yl]amino}‐1-methyl‐2‐oxo‐1,2‐dihydroquinolin‐3‐yl)oxy]‐N-methylacetamide, BI 3802, BI3802
• 실험식(Hill 표기법): C₂₄H₂₉ClN₆O₃
• CAS Number: 2166387-65-9
• Molecular Weight: 484.98
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• 저장 온도: -10 to -25°C

설명

생화학적/생리학적 작용

Potent and selective BCL6 degrader that targets BTB domain with high-affinity.
BI-3802 is a potent and selective BCL6 degrader that targets BTB domain with high-affinity (IC50 ≤3 nM by ULight assay). BI-3802 induces BCL6 polymerization (filaments formation) and SIAH1 E3 ligase-mediated ubiquitination, leading to proteasomal degradation (by 80% post 90 min 5 µM treatment in SU-DHL-4 cells) and inhibition of BCL6-dependent proliferation in a dose-depenent manner (typical dosing range 0.04 - 3 µM).