SML3744

Ac-FLTD-CMK

≥95% (HPLC)

• 동의어(들): N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone
• 실험식(Hill 표기법): C₂₆H₃₇ClN₄O₈
• CAS Number: 2376255-48-8
• Molecular Weight: 569.05
• MDL number: MFCD32874101
• UNSPSC 코드: 51111800
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: (Powder or Lyophilized powder or film)
• 저장 조건: desiccated
• 색상: white to off-white
• 저장 온도: -10 to -25°C

설명

생화학적/생리학적 작용

Ac-FLTD-CMK is a selective gasdermin D (GSDMD) clevage inhibitor (IC50 = 46.7 nM, 329 nM, 1.49 μM, respectively, against GSDMD clevage by human caspase-1, -5, -4 in cell-free enzymatic assays) that suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes, as well as reduces IL-1β release following activation of the NLRP3 inflammasome in macrophages (10 μM 4h post 200 ng/mL LPS and 0.5h before ATP or nigericin). Ac-FLTD-CMK selectively blocks GSDMD clevage by inflammatory caspases without affecting apoptotic caspases (caspase-3 IC50 >100 μM) or apoptosis.

Selective gasdermin D (GSDMD) clevage inhibitor that suppresses NLRP3 inflammasome activation and downstream pyroptosis.

주의사항

Hygroscopic

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable