SML3477

RO5166017

≥95% (HPLC)

• 동의어(들): (4S)-2-Amino-N-ethyl-4,5-dihydro-N-phenyl-4-oxazolemethanamine, (S)-4-((Ethyl(phenyl)amino)methyl)-4,5-dihydrooxazol-2-amine
• 실험식(Hill 표기법): C₁₂H₁₇N₃O
• CAS Number: 1048346-74-2
• Molecular Weight: 219.28
• MDL number: MFCD22493512
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: -10 to -25°C
• SMILES string: N1[C@H](COC1=N)CN(CC)c2ccccc2
• InChI key: PPONHQQJLWPUPH-JTQLQIEISA-N

설명

생화학적/생리학적 작용

Orally active, high-affinity, potent and selective trace amine-associated receptor 1 (TAAR1) agonist with antipsychotic-like efficacy in vivo.

RO5166017 is an orally active, high-affinity, potent and selective trace amine-associated receptor 1 (TAAR1) agonist (mouse/rat/human/monkey Ki = 1.9/2.7/31/24 nM, cAMP EC50 = 3.3/14/55/97 nM using respective HEK293 transfectants; GIRK EC50 = 8 nM with mTAAR1-expressing Xenopus oocytes; neurons firing frequency IC50 = 1.73/2.99 nM in mouse VTA/DRN slices) with good selectivity over TAAR4 and 123 other proteins. RO5166017 reduces spontaneous hyperlocomotion in Dat-/- mice (0.5 mg/kg ip.), as well as hyperlocomotion induction by cocaine or NMDAR agonist L-687,414 in wild-type (0.01-0.3 mg/kg po.), but not Taar1-knockout mice.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable