SML3415

HBX 41,108

≥98% (HPLC)

• 동의어(들): 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile, HBX 41108, HBX-41108, HBX41108
• 실험식(Hill 표기법): C₁₃H₃ClN₄O
• CAS Number: 924296-39-9
• Molecular Weight: 266.64
• MDL number: MFCD16251537
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: O=C(C1=C2C=CC(Cl)=C1)C3=C2N=C(C(C#N)=N3)C#N
• InChI: 1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H
• InChI key: BIGPXXAUSQLTQR-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

Catalytic site-targeting, uncompetitive, potent and reversible ubiquitin-specific protease USP7 inhibitor.

HBX 41,108 is a catalytic site-targeting, uncompetitive, potent and reversible ubiquitin-specific protease (USP) inhibitor (USP7/HAUSP IC50 = 420 nM) with little potency toward aspartic, serine or other non-USP cysteine proteases. HBX 41,108 exhibits antiproliferation potency in cancer cultures (HCT116 GI50 = 1 μM post 24 h treatment) by preventing USP7-mediated p53 deubiquitination and thereby promoting p53 target genes expression and inducing p53-dependent apoptosis.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable