SML3341

ML-SA5

≥98% (HPLC)

• 동의어(들): N1-(3-Chloro-2-(piperidin-1-yl)phenyl)-N4,N4-dimethylbenzene-1,4-disulfonamide
• 실험식(Hill 표기법): C₁₉H₂₄ClN₃O₄S₂
• CAS Number: 2418670-70-7
• Molecular Weight: 457.99
• MDL number: MFCD32679424
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: −20°C

설명

생화학적/생리학적 작용

ML-SA5 is a potent TRPML cation channel agonist that activates whole-endolysosomal TRPML1 (ML1) currents in DMD myoblasts at a higher potency than ML-SA1 (EC50 = 285 nM vs 10 μM). ML-SA5 ameliorates muscular dystrophy in mdx, but not ML1-knockout, mice in vivo (2 or 5 mg/kg/day i.p.) by facilitating sarcolemma repair, thereby reducing skeletal and cardiac muscle damage with no apparent toxicity to the animals.

Potent TRPML1 cation channel agonist that ameliorates muscular dystrophy in mdx, but not ML1-KO, mice and with a higher potency than ML-SA1.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable